The Effect of Honey on Plasma Malondialdehyde (MDA) Level onAlloxan-Induced hyperglycemic Rats An Experimental studies in rats Galur Wistar White Males

Bela Risqiyani Fajrilah*  -  Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA) Semarang Jl. Ipik Gandamanah Gg. Mesjid No. 28 RT. 07/02 Munjul Jaya, Purwakarta, Jawa Barat Phone 085795055890, Indonesia
Ulfah Dian Indrayani  -  Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA) Semarang Bagian Histologi Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA) Semarang, Indonesia
Qathrunnada Djam’an  -  Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA) Semarang Bagian Farmakologi Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA) Semarang Jl. Ipik Gandamanah Gg. Mesjid No. 28 RT. 07/02 Munjul Jaya, Purwakarta, Jawa Barat Phone 085795055890, Indonesia

(*) Corresponding Author
Malondialdehyde (MDA) is the end product of lipid peroxidation and a marker of free radicals. Honey is a safe sweetener proven to lower blood glucose level and contains flavonoids, vitamin A, C, E as a source of antioxidant that can capture free radicals. This study aims to determine the effect of honey on plasma MDA level ionalloxan-induced hyperglycemicrats. This was an experimental study with post-test only control group design conducted for 25 days using 18 white male Wistar rats divided into 3 groups randomly. A negative control group, group B were given honey orally at the dose of 0.54 ml/mice/day, and group C were given honey orally at the of dose 0.9 ml/head/day. Each group consisted of 6 rats. Blood plasma MDA was evaluated by Thiobarbituric Acid Reactive Substance (TBARS) test assay. One way ANOVA analysis test followed post hoc were applied for data analysis. The results showed that mean levels of MDA in group A, B, and C were 6.02 mmol/l ± 0.36, 4.37 mmol/± 0.30, and 1.12 mmol/l ± 0.11 respectively. Bivariate analysis One way ANOVA test showed a significant difference (p<0,05). Post hoc tests showed a significant differences between the study groups (p<0,05). It can be concluded that honey had an effect on the levels of malondialdehyde (MDA) in the blood plasma of alloxan-induced hyperglycemic rats.

Keywords: alloxan; honey; Malondialdehyde (MDA)

Sains Medika: Jurnal Kedokteran dan Kesehatan
is published by Fakultas Kedokteran Universitas Islam Sultan Agung Semarang, Indonesia.
Jl. Raya Kaligawe Km.4, PO BOX 1054/SM Semarang 50112
Website: https://fkunissula.ac.id/
Email: sainsmedika@unissula.ac.idsainsmedika@unissula.ac.id

ISSN: 2339-093X (Online) | 2085-1545 (Print)
DOI : 10.30659/sainsmed

This work is licensed under a Creative Commons Attribution 4.0 International License

Get a feed by atom here, RRS2 here and OAI Links here

apps