The Effect of Coating Material Variations on Sugar-Coated Tablets Curcuma Zanthorrhiza Roxb. Extract Using The Simplex Lattice Design Method

Fajaryanti Nita, Rose Malinda Andamari Wahyu Utami, Tri Nur Azizah

Abstract


Javanese turmeric (Curcuma xanthorrhiza, Roxb.) contains curcuminoids, taste of herbal medicine can be disguised, so researchers want to make sugar-coated tablets. The aim of this study was to formulate sugar-coated tablets using HPMC and PVA as gelling agents, which are essential for controlling the drug release of ethanolic extract of Javanese turmeric using Simplex Lattice Design (SLD). Javanese turmeric (Curcuma xanthorrhiza, Roxb.) was extracted by remaceration using ethanol 70%, then made into tablets using the wet granulation method. Tablets are coated by combination of HPMC and PVA which have been formulated with LSD (5 formulas). The determination of the optimum region for the curcuma extract coated tablet formulation was analyzed using Design Expert. The physical properties used were friability, hardness, and disintegration time. Formula optimum with tablet friability was chosen to be minimized within the range <1 with value 0,762; hardness was chosen in range 4 – 8 with value 7,7; then disintegration time less than 30 minutes with value 24,932. The optimum composition of HPMC and PVA in a coated preparation that can produce optimal physical properties for coated tablets of ethanol extract of Javanese turmeric (Curcuma xanthorrhiza, Roxb.) is HPMC 30 and PVA 20 with a desirability of 0,864.


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