Universitas Islam Sultan Agung - Indonesia
Effects of Isoflavones (Soybean Extract) on Luteinizing Hormone, Follicle-Stimulating Hormone Levels, and Ovarian Antral Follicle Diameter
Riri Emilia
(*) Corresponding Author
Background: Hormonal contraceptive methods that are commonly used include injections, pills, and implants. However, hormonal contraceptives are associated with various side effects, highlighting the need for natural contraceptive alternatives with minimal adverse effects. One potential natural source is soybean, which contains isoflavones. To date, however, scientific evidence regarding their effects remains limited.
Objective: This study aimed to determine the effect of isoflavones (soybean extract) on luteinizing hormone (LH), follicle-stimulating hormone (FSH) levels, and ovarian antral follicle diameter in female rats.
Methods: This study employed a posttest-only control group design and was divided into three groups. The control group received no isoflavones, while treatment group 1 (P1) received 4.5 mg of isoflavones and treatment group 2 (P2) received 9 mg of isoflavones. The intervention was administered for 15 days.
Results: One-way ANOVA analysis of LH and FSH levels and ovarian antral follicle diameter showed p-values > 0.05, indicating that administration of isoflavone doses of 4.5 mg and 9 mg did not result in statistically significant differences in LH levels, FSH levels, or ovarian antral follicle diameter in female rats.
Conclusion: Administration of isoflavones at the given doses did not significantly affect LH and FSH hormone levels or ovarian antral follicle diameter in female rats.
Keywords: Ovarian antral follicle diameter; Luteinizing hormone; Follicle-stimulating hormone
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