VIRUS AS A CAUSE OF SALIVARY GLAND DISEASES

Etis Duhita Rahayuningtyas*  -  Universitas Padjadjaran, Indonesia
Riani Setiadhi  -  Universitas Padjadjaran, Indonesia

(*) Corresponding Author
DOI: 10.30659/odj.6.1.37-42
Background: Enlargement in the extraoral region with the absence of abnormal dental and periodontal structures are sometimes seen in dental practice, sometimes followed by xerostomia. Enlargement of the acute nonsuppurative salivary glands has been associated with several types of viruses. The purpose of this paper is to review salivary gland diseases associated with non-HIV and HIV viral infections.
Discussion: Non-HIV viruses which were detected in the salivary glands including Paramyxovirus, cytomegalovirus (CMV), Hepatitis C virus (HCV), human papilloma viruses (HPV), Epstein-Barr virus (EBV), human herpes simplex virus (HHSV-8), and coxsackie virus. HIV-associated salivary gland disease typically presents with xerostomia and/or intraglandular lymph nodes, and diffuse infiltrative lymphocytosis syndrome (DILS). The most common viral infection conditions in salivary gland disorders are mumps and HIV. Enlargement and inflammation of the glandular structures will affects the control of salivary secretion by nerves. Parasympathetic nerves block conducted signals to the salivary glands, so the salivary flow is
decreased.
Conclusion: There is association between viral infection and diseases of the
salivary gland. By knowing sequelae viruses on the salivary gland, dentists are expected to understand the clinical condition and therapeutic that should be given to the patients.

Keywords: Virus; Salivary gland disease; HIV; nonHIV

  1. Wilson KF, Meier JD, Ward PD. Salivary Gland Disorders. Am Fam Physician. 2018;89(11):882-888.
  2. Malathi N, Mythili S, Vasanthi HR. Salivary Diagnostics : A Brief Review. ISRN Dent.2014;29(1):1-10.
  3. De Almeida PDV, Grégio AMT, Machado MÂN, De Lima AAS, Azevedo LR. Saliva composition and functions: A comprehensive review. J Contemp Dent Pract. 2008;9(3):072-080.
  4. Glick M. Burket’s Oral Medicine. 12th ed. Shelton, Connecticut: People’s Medical Publishing House-USA; 2015.
  5. Tucker, A.S, Miletich I, ed. Salivary Glands Development, Adaptation, and Disease. Vol 14. London: Frontiers of Oral Biology; 2010.
  6. Jeffers L. Viruses and Salivary Gland Disease ( SGD ): Lessons from HIV SGD. 2011:79-83.
  7. Bradley P, O’Hara J. Diseases of the salivary glands. Surgery. 2015;33(12):614-619.
  8. Shafer, Hine, Levy. Shafer’s Textbook of Oral Pathology. 7th ed. (Rajendran R, Sivapathasundaram B, eds.). Elsevier; 2012
  9. Schreiber A, Hershman G. Non - HIV Viral Infections of the Salivar y Glands. Oral Maxillofac Surg Clin NA. 2009;21(3):331-338. doi:10.1016/j. coms.2009.04.003.
  10. Hühns M, Simm G, Erbersdobler A, Zimpfer A. HPV Infection , but Not EBV or HHV-8 Infection, Is Associated with Salivary Gland Tumours. Biomed Res Int. 2015;2015(Nov.):10-17.
  11. Lin FC, Chen P, Tsao T, Li C, Jeng K, Tsai SC. Prevalence of human papillomavirus and Epstein – Barr virus in salivary gland diseases. J Int Med Res. 2014;42(5):1093-1101. doi:10.1177/0300060514543041.
  12. Dalpa E, Gourvas V, Baritaki S, et al. High prevalence of Human Herpes Virus 8 (HHV-8) in patients with Warthin ’ s tumors of the salivary gland. J Cilnical Virol. 2018;42(2008):182-185.
  13. Hafed L, Farag H, Shaker O, El-rouby D. Is human papilloma virus associated with salivary gland neoplasms ? An in situ-hybridization study. Arch Oral Biol. 2012;57(9):1194-1199.
  14. Alavian SM, Mahboobi N, Mahboobi N, Karayiannis P. Oral Conditions Associated with Hepatitis C Virus Infection. Saudi J Gastroenterol. 2013;19(6):245-252.
  15. Carrozzo M, Scally K. Oral manifestations of hepatitis C virus infection. World J Gastroenterol. 2014;20(24):7534-7543.
  16. Islam NM, Bhattacharyya I, Cohen DM. Salivary gland pathology in HIV patients. Diagnostic Histopathol. 2012;18(9):366-372.
  17. Nittayananta W, Chanowanna N, Jealae S, Nauntofte B, Stoltze K. Hyposalivation , xerostomia and oral health status of HIV-infected subjects in Thailand before HAART era. J Oral
  18. Pathol Madicine. 2010;39:28-34.
  19. Patel M, Ph D, Shackleton J, et al. Antifungal Effect of Mouth Rinses on Oral Candida Counts and Salivary Flow in Treatment-Naïve HIV-Infected Patients. AIDS Patient Care STDS. 2008;22(8).
  20. Patton LL. Current Strategies for Prevention of Oral Manifestations of HIV. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;121(1):29-38.
  21. Carrozzo M. Oral diseases associated with hepatitis C virus infection . Part 1 : sialadenitis and salivary glands lymphoma. Oral Dis. 2008;14(2):123-130
  22. Liao H, Gu Y, Diaz A, et al. Use of the CRISPR/ Cas9 system as an intracellular defense against HIV-1 infection in human cells. Nat Commun. 2015;10:6(March):1-10.
  23. Advisory G, Blood C, Blut A, Assessment S. Human Immunodeficiency Virus ( HIV ). Transfusin Med Hemotherapy. 2016;43(May):203-222.
  24. Mumps _ For Healthcare Providers _ CDC. https://www.cdc.gov/mumps/hcp.html. Published 2018. Accessed September 20, 2018.
  25. Silva D, Medeiros R. Pathogenesis, Diagnosis and Therapeutics in Human Cytomegalovirus Infection. J Infect Dis. 2017;5(2):37-39.
  26. Igoe A, Scofield RH. Autoimmunity and infection in Sjogren’s syndrome. Curr Opin Rheumatol. 2013;25(4):480-487.
  27. Bate SL, Dollard SC, Cannon MJ. Cytomegalovirus Seroprevalence in the United States : The National Health and Nutrition Examination. Clin Infect Dis. 2010;30345(11):1439-1447.
  28. Jacobson IRAM, Cacoub P, Maso LDAL, Harrison SA, Younossi ZM. Manifestations of Chronic Hepatitis C Virus Infection Beyond the Liver. YJCGH. 2010;8(12):1017-1029.
  29. Machado J, Reis PP, Zhang T, et al. Low prevalence of Human Papillomavirus in oral cavity carcinomas. Head Neck Oncol. 2010;12(March):1-6.
  30. Campisi G, Giovannelli L. Controversies surrounding human papilloma virus infection, head & neck vs oral cancer, implications for prophylaxis and treatment. Head Neck Oncol. 2009;1:8(March):1-7.
  31. Daley E, Dodd V, Debate R, et al. Prevention of HPV-related oral cancer : assessing dentists’readiness. Public Health. 2014;128(3):231-238.
  32. Ryerson AB, Peters ES, Coughlin SS, et al. Burden of Potentially Human Papillomavirus- associated Cancers of the Oropharynx and Oral Cavity in the US , 1998-2003. Cancer. 2008;113(November):2901-2909.
  33. Gillison ML, Chaturvedi AK, Lowy DR. HPV Prophylactic Vaccines and the Potential Prevention of Noncervical Cancers in Both Men and Women. Cancer. 2008;13(November):3036-3046.
  34. Makihara H, Goto M, Watanabe H, et al. Oral and Maxillofacial Surgery Cases Age-related EBV-associated B-cell lymphoproliferative disorders of the minor salivary gland : a case report. Oral Maxillofac Surg Cases. 2016;2(3):27-30.
  35. Voulgarelis M, Tzioufas AG. Pathogenetic mechanisms in the initiation and perpetuation of Sjogren’s syndrome. Nat Publ Gr. 2010;6(9):529-537.
  36. Sarkar PK, Patel N, Furie RA, Talwar A. Pulmonary manifestations of primary Sjogren’s syndrome. Indian J Chest Dis Allied Sci. 2015;51(May):93-101.
  37. Emamian ES, Leon JM, Lessard CJ, et al. Peripheral blood gene expression profiling in Sjogren’s syndrome. Genes Immun. 2009;10:285-296.
  38. Tzioufas AG, Kapsogeorgou EK, Moutsopoulos HM. Pathogenesis of Sjögren’s syndrome : What we know and what we should learn. J Autoimmun. 2012;39(1-2):4-8.
  39. Krishnamurthy S, Vasudeva SB, Vijayasarathy S. Salivary gland disorders: A comprehensive review. World J Stomatol. 2015;4(2):56-71.
  40. Napeñas JJ, Brennan MT, Fox PC. Diagnosis and treatment of xerostomia (dry mouth). Odontology. 2009;97(2):76-83.
  41. Proctor G. The physiology of salivary secretion. Periodontol 2000. 2016;70:11-25.
  42. Walsh LJ. Clinical aspects of salivary biology for the dental clinician. Int Dent South Africa (Australasian Ed. 2007;2(3):16-30.

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