Department of Anatomy, Faculty of Medicine, University of Jember, Jember, Indonesia. - Indonesia
ALUMINUM CHLORIDE IMPAIRED SPATIAL MEMORY, BUT NOT SENILE PLAQUES FORMATION IN THE RAT MODEL OF ALZHEIMER’S DISEASE
Background: aluminum compounds can be easily found in the environment. Aluminum contamination is the environmental factor as one of the risk factors in Alzheimer's disease (AD). In the animal model, aluminum chloride (AlCl3) causes inflammation and oxidative stress. Inflammation and oxidative stress are important pathogenesis pathways in AD. Objective: This study is to investigate whether AlCl3 can impair spatial memory and induce senile plaques formation.
Methods: we used 24 young adult Wistar rats in this study. The rats were divided into four groups; one control group and three AlCl3 treated groups with doses of 150 mg/kg, 300 mg/kg, and 600 mg/kg, respectively for 8 weeks. The spatial memory test was measured using Morris water maze and the histopathology was done by identification of senile plaques formation in the hippocampal tissue.
Results: we showed that there are significant differences between the control group and all of the AlCl3 treatment groups in the memory test, however, there is no change in the senile plaques expression in all groups.
Conclusion: in this study, we demonstrated that administration of AlCl3 for 8 weeks can cause the impaired of spatial memory without senile plaques formation.
Keywords : aluminum chloride, spatial memory, senile plaques, Alzheimer’s disease
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