COWHIDE GELATIN NANOPARTICLES AND TITANIUM-PREPARED PLATELET-RICH FIBRIN POTENTIAL IN PERIODONTITIS HEALING PROCESS
Abstract
Introduction: Based on epidemiological data, the periodontitis prevalence in Indonesia reached 96.58%. Periodontitis is a periodontal disease caused by specific microorganisms causing attachment loss, alveolar bone resorption, and periodontal pocket. The pocket which is more than 6 mm couldn’t be carried out using standard care. Therefore bone grafting is needed to fix the bone defect. Cowhide Gelatin nanoparticle (GNPs) combined with Titanium-Prepared Platelet-Rich Fibrin (T-PRF) is an innovative healing of periodontitis.
Objective: To review the potential of cowhide gelatin nanoparticles combined with titanium-prepared platelet-rich fibrin (T-PRF) as an innovation in the healing of periodontitis defects.
Literature review: Cowhide GNPs are the main ingredients for the bone replacement, which are nano-sized, biocompatible, bioactive, osteoconductive, non-toxic, and have a porous structure that supports the drug-delivery process. T-PRF contains platelets, fibrin, growth factors that can stimulate bone regeneration.
Discussion: GNPs support the attachment and proliferation of osteoblast cells and the formation of mineralized bone matrix. The contents of T-PRF, which are fibrin, platelets, and growth factors, one of TGF-β1 will produce bone formation and periodontal healing in the large number. Moreover, T-PRF has leukocyte-fibrin, which may give an antibacterial effect. Thus, GNPs combined with T-PRF have more potent properties that support each other in carrying out their functions to stimulate the healing process.
Conclusion: The combination of cowhide gelatin nanoparticles (GNPs) and titanium-prepared platelet-rich fibrin (T-PRF) has the potential to be effective in bone regeneration in periodontitis defects.
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Newman MG, Takei, HH, Klokkevold, PR. Carranza’s Clinical Periodontology. 2012. California: Elsevier.
Kubota T., Nemoto Y., Nohno K., et al. A Comparable Study of Combinational Regenerative Therapies Comprising Enamel Matrix Derivative plus Deproteinized Bovine Bone Mineral with or without Collagen Membrane in Periodontitis Patients with Intrabony Defects. Open Journal of Stomatology 2018; 8(09): 277.
Elzoghby, A.O. Gelatin-based nanoparticles as drug and gene delivery systems: reviewing three decades of research. Journal of Controlled Release 2013; 172(3): 1075-1091.
Bakopoulou, A., Georgopoulou, Α., Grivas, I., et al. Dental pulp stem cells in chitosan/gelatin scaffolds for enhanced orofacial bone regeneration. Dental Materials 2019; 35(2): 310-327.
Shin JY, Jeong SJ, Lee WK. Fabrication of porous scaffold by ternary combination of chitosan, gelatin, and calcium phosphate for tissue engineering. Journal of Industrial and Engineering Chemistry 2019; 80: 9-862.
Chen G, Deng C, Li YP. TGF-β and BMP signaling in osteoblast differentiation and bone formation. International journal of biological sciences 2012; 8(2):272.
Atalay B, Doganay, O. The Use of Platelet-Rich Fibrin in Bone Grafting. Bone Grafting 2018; 7: 95-102.
Ozdemir H, Ezirganli S, Kara MI, et al. Effects of platelet rich fibrin alone used with rigid titanium barrier. Archives of oral biology 2013; 58(5): 44-537.
Arabaci T, Albayrak M. Titaniumâ€prepared plateletâ€rich fibrin provides advantages on periodontal healing: A randomized splitâ€mouth clinical study. Journal of periodontology 2018; 89(3): 64-255.
Preshaw PM, Alba AL, dan Herrera. Periodontitis And Diabetes: A Two Way Relationship Review. J Diabetalogia 2012; 55: 21-31.
Kurniawan F, Nugroho A. Deteksi Gelatin Babi Menggunakan Sensor Emas Termodifikasi NiO Nanopartikel pada Quartz Crystal Microbalance. Jurnal Sains dan Seni ITS 2015; 4(2).
An SM, Kim MJ, Seong KY, et al. Intracutaneous Delivery of Gelatins Reduces Fat Accumulation in Subcutaneous Adipose Tissue. Toxicological research 2019; 35(4): 395.
Jaipan P, Nguyen A, Narayan RJ. Gelatin-based hydrogels for biomedical applications. MRS Communications 2017; 7(3): 26-416.
Chen S, Zhang Q, Nakamoto T, et al. Gelatin scaffolds with controlled pore structure and mechanical property for cartilage tissue engineering. Tissue Engineering Part C: Methods 2016; 22(3): 98-189.
Olgun E, Ozkan SY, Atmaca HT, et al. Comparison of the clinical, radiographic, and histological effects of titaniumâ€prepared platelet rich fibrin to allograft materials in sinusâ€lifting procedures. Journal of investigative and clinical dentistry. 2018; 9(4): e12347.
Liu Y, Sun X, Yu J, Wang J, et al. Platelet Rich Fibrin as a Bone Graft Material in Oral and Maxillofacial Bone Regeneration: Classification and Summary for Better Application. BioMed Research International 2019; 2019: 1-11.
Tunalı M, Özdemir H, Küçükodacı Z, et al. A novel platelet concentrate: titanium-prepared platelet-rich fibrin. BioMed research international. 2014; 2014.
Tunali M, Ozdemir H, Kucukodacı Z, et al. A novel platelet concentrate for guided bone regeneration: Titanium Prepared Platelet-Rich Fibrin (T-PRF). Gulhane Med J 2015; 57: 6-102.
UstaoÄŸlu G, Ercan E, Tunali M. The role of titanium-prepared platelet-rich fibrin in palatal mucosal wound healing and histoconduction. Acta Odontologica Scandinavica 2016; 74(7): 64-558.
Widyawati, SD. Pengaruh Pemberian Platelet Rich Fibrin dan Deproteinized Porous Bovine Bone Terhadap Aktivitas Transforming Growth Factor-β1 Dan Konsentrasi Osteokalsin. Skripsi 2014. Jakarta: Fakultas Kedokteran Gigi.
Pellegrini G, Farronato D, Rasperini G, et al. Soft Tissue Healing in Alveolar Socket Preservation Technique: Histologic Evaluations. The international journal of periodontics & restorative dentistry 2014; 34(4): 537.
Efremov L, Bosnakovski D, Kanjevac T. Perspectives on regeneration of alveolar bone defects. Ser J Exp Clin Res 2013; 14(4): 145-153.
Gomes PS, Daugela P, Poskevicius L et al. Molecular and Cellular Aspects of Socket Healing in the Absence and Presence of Graft Materials and Autologous Platelet Concentrates: a Focused Review. J Oral Maxillo Fac Res 2019; 10(3): p1-p18.
Deidda G, Jonnalagadda SV, Spies JW, et al. Self-assembled amyloid peptides with Arg-Gly-Asp (RGD) motifs as scaffolds for tissue engineering. ACS Biomaterials Science & Engineering 2017; 3(7): 16-1404.
Meng ZX, Wang YS, Ma C, et al. Electrospinning of PLGA/gelatin randomly-oriented and aligned nanofibers as potential scaffold in tissue engineering. Materials Science and Engineering: C 2010; 30(8): 10-1204.
Ahn CB, Kim Y, Park SJ, et al. Development of arginine-glycine-aspartate-immobilized 3D printed poly (propylene fumarate) scaffolds for cartilage tissue engineering. Journal of Biomaterials Science, Polymer edition 2018; 29(7-9): 31-917.
Elzoghby AO. Gelatin-based nanoparticles as drug and gene delivery systems: reviewing three decades of research. Journal of Controlled Release 2013; 172(3): 91-1075.
Kouro H, Kon S, Matsumoto N, et al. The novel α4B murine α4 integrin protein splicing variant inhibits α4 protein-dependent cell adhesion. Journal of Biological Chemistry 2014; 289(23):98-16389.
Kasagi S, Chen W. TGF-beta1 on osteoimmunology and the bone component cells. Cell & Bioscience 2013; 3(1): 4.
Glueck M, Gardner O, Czekanska E, et al. Induction of osteogenic differentiation in human mesenchymal stem cells by crosstalk with osteoblasts. BioResearch open access 2015; 4(1): 30-121
Wu M, Chen G, Li YP. TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease. Bone research 2016; 4: 16009.
Rahman, MS., Akhtar, N., Jamil HM., et al. TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation. Bone research 2015; 3: 15005.
Pillay V, Kumar P, Choonara YE, et al. Processing and Templating of Bioactive-Loaded Polymeric Neural Architectures: Challenges and Innovative Strategies. Recent Advances in Novel Drug Carrier Systems. InTech Publishers; 2012 :92-355.
Bakopoulou A, Georgopoulou Α, Grivas I, et al. Dental pulp stem cells in chitosan/gelatin scaffolds for enhanced orofacial bone regeneration. Dental Materials 2019; 35(2): 27-310.
Yu Q, Han FJ, Lv DS. To compare the healing of pressure sores by the use of combination therapy with platelet rich plasma and gelatin hydrogel versus platelet rich plasma and collagen. Biomedical Research 2017; 28(3): 12-22
DOI: http://dx.doi.org/10.30659/odj.7.1.73-81
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