INFEKSI PERIODONTAL SEBAGAI FAKTORRISIKO KONDISI SISTEMIK

Oedijani Santoso

Abstract


According to Riskesdas 2018 the prevalence of dental and oral diseases in Indonesia is still high (57.6%) and the most cases are caries and periodontal disease. Periodontal tissue infection is a local oral infection that can be a focal oral infection, and has a risk of affecting systemic conditions. Microorganisms, toxins and inflammatory reactions in infected periodontal tissues can spread systemically to other parts of the body, thatcan cause infections in the area or worsen existing conditions. Systemic conditions that can be affected by periodontal tissue infections including coronary heart disease / arterosclerosis, stroke, diabetes mellitus, pregnancy, chronic pulmonary obstruction, acute respiratory infections. The purpose of this literature review is to refresh about oral focal infection, as well as more convincing that periodontal infection was a risk factor for systemic conditions, in terms of inflammatory reactions.
Influencing inflammatory reactions are inflammatory mediators, including interleukin (IL-1α, IL-β, IL-6, IL-8), tumor necotic factors (TNFα) and prostaglandin E2 (PGE2). Biological mechanisms support the role of periodontal infection as a potential risk factor for a number of systemic conditions.Future multidisciplinary research should better illustrate the role of periodontal infections in systemic health, so that the influence between periodontal infections and systemic conditions such as premature LBW, diabetes, cardiovascular and cerebrovascular diseases, and respiratory diseases will be increasingly proven


Keywords


inflammatory reaction; periodontal infection; systemic risk

Full Text:

PDF

References


Riskesdas 2018. Kementrian Kesehatan RI, Jakarta, 2019

Osten, DHV, Infeksi fokal (online), (http:/www.scribd.com, diakses April 2018; 2012.

I Gusti AA SW. Kerusakan Gigi merupakan fokal infeksi penyebab timbulnya penyakit sistemik, Jurnal Kesehatan Gigi.2013; 1 (1): 1-6

Slots J. Periodontology : past, present. Perspectives. Periodontol 2000. 2013; 62: 7-19

Ghali RE. The potential link between periodontal and systemic disease – an overview. JAMR. 2011; 1(1): 24-35

Cullinan MP, Ford PJ, Seymour GJ. Periodontal disease and systemic health: current status. Aust Dent J. 2009;54: S62–S9.

Bansal M, Rastogi S, Vineeth NS. Influence of periodontal disease on systemic disease: inversion of a paradigm: a review. Journal of Medicine and Life. 2013; 6(2): 126–30

Pizzo G, Guiglia R, Russo LL. Campisi G. Dentistry and internal medicine: from the focal infection theory to the periodontal medicine concept. European Journal of Internal Medicine. 2010; 21(6): 496–502

Shangase SL, Mohangi GU, Hassam-Essa S, Wood NH. The association between periodontal and systemic health: an overview. SADJ. 2013; 1(8): 10-2

Winning L, Linden GJ. Periodontal and systemic disease. BDJ. 2015

Igari K, Kudo T, Toyofuku T, Inone Y, Iwai T. Association between periodontal and the development of systemic disease. Oral Biol Dent. 2014

Higashi Y, Goto C, Hidaka T, Soga J, Nakamura S, Fujii Y, Hata T, Idei N, Fujimura N, Chayama K. Oral infection-inflammatory pathway, periodontitis, is a risk factor for endothelial dysfunction in patients with coronary artery disease. Atherosclerosis. 2009;206: 604-10.

Yakob M, Söder B, Meurman JH, Jogestrand T, Nowak J, Söder PÖ. Prevotella nigrescens and Porphyromonas gingivalis are associated with signs of carotid atherosclerosis in subjects with and without periodontitis. J Periodontal Res. 2011;46: 749-55.

Andriankaja O, Trevisan M, Falkner K, Dorn J, Hovey K, Sarikonda S, Mendoza T, Genco R. Association between periodontal pathogens and risk of nonfatal myocardial infarction. Community Dent Oral Epidemiol. 2011;39: 177-85.

Thakare KS, Deo V, Bhongade ML. Evaluation of the C-reactive protein serum levels in periodontitis patients with or without atherosclerosis. Indian J Dent Res. 2010;21: 326-9.

Nakajima T, Yamazaki K. Periodontal disease and risk of atherosclerotic coronary heart disease. Odontology. 2009;97:84-91.

Reyes L, Herrera D, Kozarov E, Rolda S, Progulske-Fox A. Periodontal bacterial invation and infection contribution to artherosclerotic pathology. J Periodontol. 2013. 84

Aarabi G, Eberhard J, Reissman DR, Heydecke G, Seedorf U. Interaction between periodontal disease and artherosclerotic vascular disease—fact or fiction? Artherosclerosis. 2015: 241; 555-60

Hosomi N, Aoki S, Matsuo K,et al. Association of serum anti-periodontal pathogen antibody with ischemic stroke. Cerebrovascular Diseases. 2012; 34(5-6): 385–92

Preshaw PM. Periodontal disease and diabetes, J Dent.2009; 37: 575-7

Neqrato CA, Tarzia O, Javanovic L, Chinellato LE. Periodontal disease and Diabetes mellitus. J Appl Oral Sci. 2013; 21(1): 1-12

Ritchie CS. Mechanistic link between type 2 diabetes and periodontitis. J Dent. 2009; 37: 578-9

Lazenby MG, Crook MA. The innate immune system and diabetes mellitus: the relevance of periodontitis? A hypothesis. Clinical Science. 2010; 119(10); 423–9

Preshaw PM, Alba AL, Herrera D, Jepsen S, Konstantinidis A, Makrilakis K, Taylor R. Periodontitis and diabetes: a two-way relationship. Diabetologia. 2012;55:21–31

Lakschevitz F, Aboodi G, Tenenbaum H, Glogauer M. Diabetes and periodontal diseases: interplay and links. Current Diabetes Reviews. 2011; 7: 433-9

Katagiri S, Nitta H, Nagasawa T, et al. Effect of glycemic control on periodontitis in type 2 diabetic patients with periodontal disease. J Diabet Invest. 2013; 4(3): 320–5

Oedijani-Santoso, Wildam Aditya, Dwi Retnoningrum. Hubungan kebersihan mulut dan gingivitis ibu hamil terhadap kejadian BBLR kurang bulan di RSUP dr Kariadi dan jejaringnya. J M Med Indones. 2009; 43(6): 288-93

Madianos PN, Bobetsis YA, Offenbacher S. Adverse pregnancy outcomes (APOs) and periodontal disease: pathogenic mechanisms. J Clin Periodontol. 2013; 40: S170-S80

Sanz M, Kornman K. Working group 3 of Joint EFPPAPw. Periodontitis and adverse pregnancy outcomes: consensus report of the Joint EFP/AAP workshop on periodontitis and systemic diseases. J Clin Periodontol. 2013; 40: S164-S9

Bansal M, Khatri M, Kumar A, Bhatia G. Relationship between maternal periodontal status and preterm low birth weight. Rev Obstet Gynecol. 2013; 6(3): 135-40

Kukkumalla MA, Thomas BS, Pralhadkushtagi, Kaur. Periodontal disease as a risk factor for preterm delivery and low birth weight. J Dent Med Sci. 2014; 13(8): 12-5

Lopez NJ, Uribe S, Martinez B. Effect of periodontal treatmenton preterm birth rate: a systematic review of meta-analyses. Periodontol 2000. 2015; 67: 87-130

Prasanna SJ. Causal relationship between periodontitis and chronic obstructive pulmonary disease. J Indian Society Periodontology. 2011; 15(4): 359-65

Deo V, Bhongade ML, Ansari S, Chavan RS. Periodontitis as a potential risk factor for chronic obstructive pulmonary disease: a retrospective study. Indian J Dent Res. 2009;20:466–470

Liu Z, Zhang W, Zhang J, Zhou X, Zhang L, Song Y, Wang Z. Oral hygiene, periodontal health and chronic obstructive pulmonary disease exacerbations. J Clin Periodontol. 2012;39:45–52

Thanabalan D, Sheeja. Association between periodontitis and respiratory disease-a review. JDent Med Sci. 2014; 13(1): 5-8




DOI: http://dx.doi.org/10.30659/odj.6.2.141-152

Refbacks

  • There are currently no refbacks.


Lisensi Creative Commons
This work is licensed under a Lisensi Creative Commons Atribusi-BerbagiSerupa 4.0 Internasional.
Contact us: Odonto Dental Journal: Jl. Raya Kaligawe Km.4, PO BOX 1054/SM Semarang, Central Java, Indonesia, 50112. Email: odontodentaljournal@unissula.ac.id