TANTANGAN FARMAKOLOGI PENGGUNAAN STEROID TOPIKAL PADA PASIEN ORAL LICHEN PLANUS

Revi Nelonda, Nanan Nur’aeny, Irna Sufiawati

Abstract


Background: Oral lichen planus (OLP) is a chronic autoimmune disease sprinkled by T cells on the oral mucosal surface. The goal of OLP treatment is to eliminate erythema, ulceration and relieve symptoms. Corticosteroids are the first line in the treatment of OLP, either systemically or topically. The problem arises when using topical steroids, namely the time of topical steroid attachment to the oral mucosa, especially in cases of OLP with clinical desquamative gingivitis. Some studies suggest that the use of individual gingival tray can overcome this problem. Objective: To provide information on topical steroid use in OLP cases with desquamative gingivitis clinical signs.
Case Management: Women, age 31, complain that pain with burning on the lips and mouth is aggravated by spicy food. Intraoral examination shows irregular white plaques on the buccal, labial and dorsal mucosa of the tongue accompanied by diffuse erythema in the anterior gingiva of the upper and lower jaws. Patients diagnosed with OLP. Lesions improve 3 months after topical steroid administration, except lesions on the gingiva. Gingival individual tray is then used to obtain adequate attachment of topical steroids on the gingiva surface. The gingiva showed significant improvement after a month later.
Conclusion: The use of topical steroid concoctions applied to the gingival individual tray is effective in treating OLP lesions especially with clinical signs of desquamative gingivitis.

Keywords


Oral lichen planus; topical steroids; individual gingival tray

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References


Kini G, Nagaratna D, Saha A. Therapeutic Management of Oral Lichen Planus : A Review for the Clinicians. World J Dent. 011;2(3):249–53.

Koregol AC, Dorle S, Koregol S, Kalburgi NB, Sireesha KS, Wagh AK. Gingival Lichen Planus : A Rare Clinicohistopathologic Report. J Heal Sci Res. 2018;9(1):15–9.

Prasad S, Solanki S, Br C, Tandon S. The Magic of Herbal Curcumin Therapy in Recurrent Oral Lichen Planus. Am J Ethnomedicine. 2014;1(1):96–101.

Burgess J. 3 CE credits The Management of Oral Lichen Planus. 2015;

Azizi A, Rezaee M. Comparison of periodontal status in gingival oral lichen planus patients and healthy subjects. Dermatol Res Pract. 2012;2012(i).

Bajaj DR, Khoso NA, Devrajani BR, Matlani BL, Lohana P. Oral lichen planus: a clinical study. J Coll Physicians Surg Pak. 2010;20(October):154–7.

Thongprasom K. Oral lichen planus: Challenge and management. Oral Dis. 2018;24(1–2):172–3.

Adamo D, Mignogna MD, Pecoraro G, Aria M, Fortuna G. Management of reticular oral lichen planus patients with burning mouth syndrome-like oral symptoms: a pilot study. J Dermatolog Treat [Internet]. 2018;29(6):623–9.

Parashar P. Oral lichen planus. Otolaryngol Clin N Am. 2011;44(1):89–107, vi.

Suresh SS, Chokshi K, Desai S, Malu R, Chokshi A. Medical management of oral lichen planus: A systematic review. J Clin Diagnostic Res. 2016;10(2):ZE10-ZE15.

Hambly JL, Haywood A, Hattingh L, Nair RG, Coast G, Medicine O, et al. A comparison between self-formulation dexamethasone and compounded formulation dexamethasone mouth rinse for oral lichen planus : A pilot randomized cross-over

trial. J Investig Clin Dent. 2016;8(3):1–14.

Ghabanchi J, Najafi RB, Haghnegahdar S. Treatment of Oral Inflammatory Diseases with a New Mucoadhesive Prednisolone Tablet Versus Triamcinolone Acetonide Paste. Iran red Crescent

Med J. 2009;11(2):155–9.

Alerraqi E. Steroid Therapy in Oral Lichen Planus. J Steroids Horm Sci [Internet]. 2016;7(2):10–3.

Pauly G, Kashyap R, Kini R, Rao P, Bhandarkar G. Reticular oral lichen planus : The intra-oral-web-A case report. Gulhane Med J. 2015;57:378–84.

Bagan J, Compilato D, Paderni C, Campisi G, Panzarella V, Picciotti M, et al. Topical Therapies for Oral Lichen Planus Management and their Efficacy: A Narrative Review. Curr Pharm Des [Internet]. 2012;18(34):5470–80.

Kumar Jena A, Ranjan Das S. a Systematic Review of Management of Oral Lichen Planus. J Evol Med Dent Sci. 2016;5(32):1763–7.

Goel K, Shrestha A, Marla V, Maharjan I. Vesicular lesion of gingiva diagnosed as bullous lichen planus : Management with combination therapy. J Case Rep Images Dent. 2017;3:1–5.

Park S, Choi Y, Lee H, Kim Y, Kim S, Yun P, et al. Factors affecting treatment outcomes in patients with oral lichen planus lesions : a retrospective study of 113 cases. J Periodontal Implant Sci. 2018;48(4):213–23.

Siponen M. Oral Lichen Planus – Etiopathogenesis and Management. 2017. 112 p.

Alrashdan MS, Cirillo N, McCullough M. Oral lichen planus: a literature review and update. Arch Dermatol Res. 2016;308(8):539–51.

Cheng YSL, Gould A, Kurago Z, Fantasia J, Muller S. Diagnosis of oral lichen planus: a position paper of the American Academy of Oral and Maxillofacial Pathology. Oral Surg Oral Med Oral Pathol Oral Radiol

Muller S. Oral lichenoid lesions: Distinguishing the benign from the deadly. Mod Pathol [Internet]. 2017;30(s1):S54–67.

Radwan-oczko M, Zwyrtek E, Owczarek JE, Szczesniak D. Psychopathological profile and quality of life of patients with oral lichen planus. J Appl Oral Sci. 2018;26(e20170146):1–9.

Karthikeyan P, Aswath N. Stress as an etiologic co-factor in recurrent aphthous ulcers and oral lichen planus. J Oral Sci. 2016;58(2):237–40.

Boras VV, Savage NW, Brailo V, Å krinjar I, Valter

K, Alajbeg I, et al. The significance of oral and systemic factors in Australian and Croatian patients with oral lichen planus. Acta Dermatovenerologica Croat. 2014;22(2):97–102.

Journal T. Lichen planus and its management. Pharm J. 2010;(June):1–4.

Anil S. Plasma cell gingivitis among herbal toothpaste users: A report of three cases. J Contemp Dent Pract. 2007;8(4):60–6.

Sankar V, Hearnden V, Hull K, Juras DV, Greenberg MS, Kerr AR, et al. Local drug delivery for oral mucosal diseases : challenges and opportunities. Oral Dis. 2011;17(December 2010):73–84.

Bulman SE, Coleman CM, Murphy JM, Medcalf N, Ryan AE, Barry F. Pullulan: A new cytoadhesive for cell-mediated cartilage repair. Stem Cell Res Ther [Internet]. 2015;6(1):1–12.




DOI: http://dx.doi.org/10.30659/odj.6.1.30-36

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