Lukman Hakim Hidayat


Background: Erythema multiforme is an acute and a self-limiting mucocutaneous
hypersensitivity reaction triggered by infections and medications. The most
common predisposing factors for erythema multiforme is infection with herpes
simplex virus. Herpes associated erythema multiforme (HAEM) is an acute
exudative dermatic and mucosal disease caused by the infecting herpes simplex
virus. Most common ages is in childhood.
Case and management: We report a case of recurrent herpes-associated
erythema multiforme in a 23-year-old female patient, with crustae lesion in the
lips and in pain. The patient had history of HSV infection. The patient had a
fever and prodromal before the lesion emerge. And the cutaneous lesion was
mistaken with the pimpleacne.
Conclusions: Although the etiology of EM is still often unknown, infections with
herpes simplex virus have been implicated as common predisposing a possible
precipitating factor. This case illustrates the association of the occurrence of EM
with a herpes simplex virus (HSV) infection and how to managed the lesion


Erythema multiforme, Herpes associated erythema multiforme, lips lesion, HSV infection

Full Text:



Kishore, Sunil R Panat, Ashish Aggarwal, Nitin Upadhyay NA. Herpes Associated Erythema Multiforme-A Diagnostic Dilemma Mallika. 2009;01(02). Available from: http://www.billbabin.com/can-karate-turn-back-the-clock

Chen Y-C, Chang C-H. Herpes Simplex Virus -Associated Recurrent Erythema Multiforme: The Implication of MHC Class Molecules on Susceptibility. Dermatol Sin. 2008;165–70.

Issrani R. Etiopathogenesis of Erythema Multiforme - A Concise Review. Adv Dent Oral Heal [Internet]. 2017;5(4). Available from: http://www.juniperpublishers.com/adoh/ADOH.MS.ID.555669.php

Kamala KA, Ashok L, Annigeri RG. Herpes associated erythema multiforme. Contemp Clin Dent [Internet]. 2011;2(4):372–5. Available from: https://www.ncbi.nlm.nih.gov/pubmed/22346171

Weston william L. Herpes-Associated Erythema Multiforme. J Invest Dermatol. 2005;

Z. S, M. M, A. E. Erythema Multiforme Associated with Misoprostol: A Case Report. Am J Ther. 2016;23(5):2–5.

Aurelian L, Ono F, Burnett J. Herpes simplex virus (HSV)-associated erythema multiforme (HAEM): A viral disease with an autoimmune component. Vol. 9, Dermatology online journal. 2003. 1 p.

Farthing P, Bagan J, Scully C. Can China Counter A Global Recession. 2005;44(Iv):261–7.

Léauté-Labrèze C, Lamireau T, Chawki D, Maleville J, Taïeb A. Diagnosis, classification, and management of erythema multiforme and Stevens-Johnson syndrome. Arch Dis Child [Internet]. 2000 Oct;83(4):347–52. Available from: https://www.ncbi.nlm.nih.gov/pubmed/10999875

Gürkan A, Sarikaya E, Demirkesen C, Yilmaz G, Midilli K. The Overlap of Fixed Drug Eruption and Human Herpes Virus Type II Associated Erythema Multiforme. 2018.

Sen P, Chua SH. A case of recurrent erythema multiforme and its therapeutic complications. Ann Acad Med Singapore. 2004;33(6):793–6.

Osterne RLV, Matos Brito RG de, Pacheco IA, Alves APNN, Sousa FB. Management of erythema multiforme associated with recurrent herpes infection: a case report. J Can Dent Assoc. 2009;75(8):597–601.

Blyta Y, A K, M F, A G, N A. Multiforme Erythema, In Child, After Repeated Herpes Simplex Infections – Case Presentation. J Clin Exp Dermatology [Internet]. 2011;02(05). Available from: https://www.omicsonline.org/multiforme-erythema-in-child-after-repeated-herpes-simplex-infections-case-presentation-2155-9554.1000127.php?aid=1863

Koopaie M. Burket’s Oral Medicine: 12th ed 2015 (in persian - vol 1). 2018.

DOI: http://dx.doi.org/10.30659/odj.5.2.152-156


  • There are currently no refbacks.

Analytics Made Easy - StatCounter

Lisensi Creative Commons
Ciptaan disebarluaskan di bawah Lisensi Creative Commons Atribusi 4.0 Internasional. ODONTO : Dental Journal is published by Faculty of Dentistry, Universitas Islam Sultan Agung, Indonesia