EFFECTS OF MANGOSTEEN SKIN GEL EXTRACTS ON INCREASING THE NUMBER OF FIBROBLASTS IN THE HEALING PROCESS OF RATS PERIODONTITIS

Adisty restu Poetri, Anggun Feranisa, Adhiatarika Rismadianti

Abstract


Background: Periodontitis is one of the most common periodontal diseases in Indonesia. Inflammation and the bacteria that cause periodontitis can be treated by providing additional therapy in the form of a gel by the dentist. Mangosteen peel extract gel contains xanthones which function as antibacterial and anti-inflammatory that will accelerate the inflammatory phase. This study aims to determine the effectiveness of a gel made from mangosteen peel extract to increase the number of fibroblast cells on the healing process of periodontitis in Wistar rats.
Methods: This is an experimental laboratory with post test only design. The treatment group composed of 50% mangosteen peel extract gel, 75% mangosteen peel extract gel, 25% metronidazole gel, and metronidazole plus mefenamic acid gel which were applied to Wistar rats after periodontitis induced.
Results: The research data were analyzed by One Way ANOVA and exhibited a significance score of p = 0.000 (p<0.05) which indicated a significant difference. In the inter-group test with Bonferroni post hoc, it was found that there was no significant difference between the 75% mangosteen peel extract gel group and 25% metronidazole gel group with a score of p = 0.709 (p>0.05).
Conclusion: The conclusion of this research showed that mangosteen peel extract gel was effective in increasing the number of fibroblast cells in the recupiration process of periodontitis


Keywords


Mangosteen peel extract gel, metronidazole gel, number of fibroblast cells

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DOI: http://dx.doi.org/10.30659/medali.4.3.77-83

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