COMPARISON OF THE EFFECTIVENESS OF FERACRYLUM 1% AND FERACRYLUM 4% IN STOPING BLOODING AFTER GINGIVA INCISION
Abstract
Background: Bleeding is often found in dental practice. Excessive bleeding can hinder wound healing. For the surgeon to achieve rapid and effective hemostasis is important. Therefore, a topical hemocoagulation solution is given to help control surface bleeding by applying it locally. One such topical agent is Feracrylum. Feracrylum is a polymer of polyacrylic acid containing 0.05 to 0.5% iron. Feracrylum iron element will react with albumin and then convert water-soluble fibrinogen into water-insoluble fibrin which then forms a coagulum. This study aims to compare the effectiveness of Feracrylum 1% and Feracrylum 4% in stopping bleeding after gingival incision.
Method: This study is a true experimental study that includes 3 treatment groups, namely the group without being given hemostatic agents, the group being given Feracrylum 1%, and the group being given Feracrylum 4%, each group consisting of 9 rats. Data were collected by calculating the bleeding time from the start of bleeding until the bleeding stopped after the gingival incision using a stopwatch and then recorded. Data analysis using Shapiro-Wilk, homogeneity test using Levene Test, nonparametric test using Kruskal-Wallis and Mann Whitney.
Result: The results showed that the average bleeding time in the group without hemostatic agents, the group receiving 1% Feracrylum, and the group receiving Feracrylum 4% was 221 seconds, 103 seconds, and 50 seconds. The results of the Kruskal-Wallis and Mann Whitney showed that there was a significant difference in bleeding time between groups.
Conclusion: The conclusion of this study is that the application of Feracrylum 4% was faster in stopping bleeding compared to the application of Feracrylum 1% after gingival incision in wistar rats.
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Lijaya, L. S., Adriatmoko, W. and Cholid, Z. (2014a) ‘Perpanjangan Waktu Perdarahan pada Pemberian Perasan Bawang Merah (Allium ascalonicum)’, e-Jurnal Pustaka Kesehatan, 2(3), pp. 542–546.
Wuisan, J., Hutagalung, B. and Lino, W. (2015) ‘Pengaruh Pemberian Ekstrak Biji Pinang (ARECA CATECHU L.) terhadap Waktu Perdarahan Pasca Ekstraksi Gigi pada Tikus Jantan Wistar (RATTUS NORVEGICUS L.)’, Jurnal Ilmiah Sains, 15(2),
Aslam, S. et al. (2013) ‘A Double Blind Study on the Efficacy of Local Application of Hemocoagulase Solution in Wound Healing’, The Journal of Contemporary Dental Practice, 14(3), pp. 394–400.
Dharmawan, L., Soesanto, R. and Bahar, M. L. (2012) ‘Pengaruh Pemberian Feracrylum 1% terhadap Waktu Perdarahan pada Luka Pasca Pencabutan Gigi (Metode Eksperimen dengan Hewan Coba Marmot/Cavia cobaya)’, J. Oral and Maxillofacial Surgery, 1(1), pp. 1–5.
Chauhan, M. K. and Kumari, M. (2017) ‘Feracrylum: an Effective and Safe Topical Haemostatic Agent’, World Journal of Pharmaceutical Research, 6(10), pp. 319–325. doi: 10.20959/wjpr201710-9372.
Laddha, A. K. et al. (2014b) ‘A Prospective Comparison of Topical Feracrylum Citrate Versus Adrenaline as Haemostatic Agent in Hypospadias Surgery in Children’, African Journal of Paediatric Surgery, 11(3), pp. 215–218. doi: 10.4103/0189-6725.137328.
Lahoti, B. K. et al. (2010) ‘Hemostasis During Hypospadias Surgery Via Topical Application of Feracrylum Citrate: a Randomized Prospective Study’, J Indian Assoc Pediatr Surg, 15(3), pp. 87–89. doi: 10.4103/0971-9261.71746.
Ermawati, T., Harmono, H. and Kartikasari, D. (2021) ‘Effectiveness of Robusta Coffe Bean Extract Gel on Collagen Fibers Density in Post-Gingivectomy Wound Healing’, ODONTO Dental Journal, 8(1), pp. 45–53. Available at: http://jurnal.unissula.ac.id/index.php/odj/article/view/10912/5581.
Irmawartini and Nurhaedah (2017) Metodologi Penelitian. Edisi tahu. Kementrian Kesehatan Republik Indonesia. Available at: http://bppsdmk.kemkes.go.id/pusdiksdmk/wp-content/uploads/2017/11/Daftar-isi-Metodologi-Penelitian_k1_restu.pdf.
Fakhrurrazi, Hakim, R. F. and Chairunissa, A. (2020) ‘Efek Ekstrak Daun Ceremai (Phyllanthus Acidus (L.) Skeels) terhadap Penyembuhan Luka Mukosa Tikus Wistar (Rattus Norvegicus)’, Cakradonya Dental Journal, 12(2), pp. 119–125. doi: https://doi.org/10.24815/cdj.v12i2.18443.
Sinulingga, S. et al. (2017) ‘Hemostatic Effect of Ethanol Extract of Piper betle, Linn Leaves to Male Mice’, Molekul, 12(1), pp. 23 – 29. doi: 10.20884/1.jm.2017.12.1.264.
Hermawan, R. and Lutfianto, B. (2012) ‘Efektivitas Obat Hemostatik Topikal Feracrylum 1% dalam Menghentikan Perdarahan Pasca Pencabutan Gigi pada Pasien Pencabutan Gigi di RSGM-P Universitas Muhammadiyah Yogyakarta’.
Wahyuni A, Nurdiana Dewi, Lia Yulia Budiarti. (2016). Uji Efektivitas Antibakteri Sediaan Tunggal Dibandingkan Kombinasi Seduhan Daun Teh Hijau (Camellia sinensis) Dan Madu(Studi in Vitro terhadap Jumlah Koloni Bakteri Rongga Mulut) Tinjauan pada Mahasiswa PSKG FK Unlam Banjarmasin Angkatan 2011-2013. Banjarmasin: Universitas Lambung Mangkurat. Dentino Jurnal Kedokteran Gigi Vol I. No 2. September 2016
Nuryati (2017) Farmakologi: Bahan Ajar Rekam Medis Informasi Kesehatan. 1st editio. Edited by Dina Mustafa. Surakarta: Kementrian Kesehatan Republik Indonesia. Available at: http://bppsdmk.kemkes.go.id/pusdiksdmk/wp-content/uploads/2017/11/FARMAKOLOGI-RMIK_FINAL_SC_26_10_2017.pdf.
Singh, K. K. et al. (2016) ‘Role of local instillation of one percent feracrylum and haemocogulase on wound healing’, International Journal of Research in Medical Sciences, 4(1), pp. 169–176. doi: http://dx.doi.org/10.18203/2320-6012.ijrms20160026.
Valse, D. and Kumaraswamy, N. H. (2021) ‘To evaluate the role of Feracrylum (1%) as hemostatic agent in Tonsillectomy’, Indian J Otolaryngol Head Neck Surg, 73(2), pp. 240–245. doi: https://doi.org/10.1007/s12070-021-02515-x.
Umar, I. and Sujud, R. W. (2020) ‘Hemostasis dan Disseminated Intravascular Coagulation (DIC)’, Journal of Anaesthesia and Pain, 1(2), pp. 19–32. doi: http://dx.doi.org/10.21776/ub.jap.2020.001.02.04.
DOI: http://dx.doi.org/10.30659/medali.4.2.163-169
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