The Potency of miRNA 221-3p as a Molecular Biomarker Of Temporomandibular Disoder: Narrative Review
DOI:
https://doi.org/10.30659/odj.12.3.241-250Abstract
United States. The trigeminal nerve might be the source of orof facial pain. Pain can be difficult to diagnose and treat due to the variability of pain complaints. miRNA 221-3p could be a potential biomarker for pain. Genetic polymorphisms and genetic mutations can lead to changes in the activity of inflammatory mediators, sex hormones, matrix-degrading enzymes, and the immune system, which affect bone remodeling homeostasis in the temporomandibular joint.
Method: Scientific databases PubMed, Scopus, and Google Scholar were searched for articles published between 2013 and 2023 in order to conduct the study. 168 carefully selected publications providing information on possible biomarkers, particularly miRNA 221-3p, were included in the review of the literature
Result: Genetic polymorphisms and genetic mutations can lead to changes in the activity of inflammatory mediators, sex hormones, matrix-degrading enzymes, and the immune system, which affect bone remodeling homeostasis in the temporomandibular joint. In addition, activity changes were also observed in neurotransmitters and pain receptors, which resulted in relatively high pain sensitivity. Thus, this condition also increases susceptibility to TMD. Genetic analysis and biomarkers of temporomandibular disorders may improve sensitivity and specificity measures in diagnosing and treating patients with TMD
Conclusion:
As a multifactorial disease, genetic factors are risk factors for TMD. Genetic polymorphisms and genetic mutations can lead to changes in the activity of inflammatory mediators, sex hormones, matrix-degrading enzymes, and the immune system, which affect bone remodeling homeostasis in the TMDReferences
Shrivastava M, Battaglino R, Ye L. A comprehensive review on biomarkers associated with painful temporomandibular disorders. Vol. 13, International Journal of Oral Science. Springer Nature; 2021.
Lövgren A, Häggman‐Henrikson B, Visscher CM, Lobbezoo F, Marklund S, Wänman A. Temporomandibular pain and jaw dysfunction at different ages covering the lifespan – A population based study. European Journal of Pain. 2016 Apr 27;20(4):532–40.
Svensson P, Kumar A. Assessment of risk factors for oro‐facial pain and recent developments in classification: implications for management. J Oral Rehabil. 2016 Dec 20;43(12):977–89.
Merskey H, Bogduk N. Classification of Chronic Pain. IASP Task Force on Taxonomy. 2nd ed. Seattle: IASP Press; 1994.
Velly A. Orofacial Pain Biomarkers. Orofacial Pain Biomarkers. 2017.
Bustin S. Molecular Biology of the Cell, Sixth Edition; ISBN: 9780815344643; and Molecular Biology of the Cell, Sixth Edition, The Problems Book; ISBN 9780815344537. Int J Mol Sci. 2015 Nov 26;16(12):28123–5.
Gassling V, Hampe J, Açil Y, Braesen JH, Wiltfang J, Häsler R. Disease-Associated miRNA-mRNA Networks in Oral Lichen Planus. PLoS One. 2013 May 27;8(5).
Chen HC, Tseng YK, Chi CC, Chen YH, Yang CM, Huang SJ, et al. Genetic variants in microRNA-146a (C > G) and microRNA-1269b (G > C) are associated with the decreased risk of oral premalignant lesions, oral cancer, and pharyngeal cancer. Arch Oral Biol. 2016 Dec;72:21–32.
Jonas S, Izaurralde E. Towards a molecular understanding of microRNA-mediated gene silencing. Nat Rev Genet. 2015 Jul 16;16(7):421–33.
Nylander E, Ebrahimi M, Wahlin Y, Boldrup L, Nylander K. Changes in miRNA expression in sera and correlation to duration of disease in patients with multifocal mucosal lichen planus. Journal of Oral Pathology & Medicine. 2012 Jan 21;41(1):86–9.
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
This work is licensed under a Creative Commons Attribution 4.0 International License.
