THE ROLE OF VITAMIN D SUPPLEMENTATION FOR HEAD AND NECK CANCER : A LITERATURE REVIEW
DOI:
https://doi.org/10.30659/odj.6.1.59-65Keywords:
head and neck cancer, quality of life, recurrence, vitamin DAbstract
Background: Vitamin D has several roles, namely physiological function of calcium and bone metabolism, cell growth and differentiation, immune and cardiovascular function. Vitamin D deficiency can cause the risk of cancer. Head and neck cancer is one of the cancers that occur due to vitamin D deficiency in the body. This literature review was to asses and evaluate the impact and benefits of vitamin D supplementation for head and neck cancer.Discussion: A study found an association between vitamin D supplementation and a low risk of recurrence in conditions of high total vitamin D levels. Another study found a significant increase in quality of life (QOL). The primary mechanism of vitamin D action is mediated through binding of either 1,25(OH)2D3 (active form) or 25(OH)D (less active form) to the VDR, which is a member of the nuclear receptor superfamily of steroid and thyroid hormones with gene-regulatory and consequent anti-proliferative properties.
Conclusions: Vitamin D supplementation provides a role in improving the condition of patients with head and neck cancer. Both in terms of suppressing recurrence and in terms of increasing quality of life
References
Lips PÃ. Vitamin D physiology. 2006;92:4-8. doi:10.1016/j.pbiomolbio.2006.02.016
Oa L, London P, Commons C, License A. Kingsley K , Bergman C , Keiserman M , Mobley C . Oral cancer risk and vitamin D status , intake , and supplementation : A review . OA. 2013;1(1).
Maria S, Ferreira S, Henrique M, et al. Prevalence of hypovitaminosis D and its association with oral lesions in HIV-infected Brazilian adults. Rev Soc Bras Med Trop. 2016;49(1):90-94.
Orkin C, Wohl DA, Williams A, Deckx H. Vitamin D Deficiency in HIV : A Shadow on Long-Term Management ? AIDS Rev. 2014:59-74.
Tsiaras WG, Weinstock MA. Factors Influencing Vitamin D Status. 2011;25(2):115-124. doi:10.2340/00015555-0980
Lopiccolo MC, Lim HW. Vitamin D in health and disease. 2010;2:224-229.
Lake J, Adam J. Vitamin D in HIV-Infected Patients. NIH Public Access. 2011;8(3):133-141. doi:10.1007/s11904-011-0082-8.Vitamin
Feldman BJ. The role of vitamin D in reducing cancer risk and progression. Nat Publ Gr. 2014;14(5):342-358. doi:10.1038/nrc3691
Vashi PG, Trukova K, Lammersfeld CA, Braun DP, Gupta D. Impact of oral vitamin D supplementation on serum 25-hydroxyvitamin D levels in oncology. Nutr J. 2010;9(1):60. doi:10.1186/1475-2891-9-60
Garland CF, Garland FC, Gorham ED, et al. The Role of Vitamin D in Cancer Prevention. 2006;96(2):252-261. doi:10.2105/AJPH.2004.045260
Anand A, Singh S, Sonkar AA, Husain N. Expression of vitamin D receptor and vitamin D status in patients with oral neoplasms and effect of vitamin D supplementation on quality of life in advanced cancer treatment. Contemp Oncol. 2017;21(2):145-151.
Grimm M, Cetindis M, Biegner T, Lehman M, Munz A, Teriete P. Serum vitamin D levels of patients with oral squamous cell carcinoma ( OSCC ) and expression of vitamin D receptor in oral
precancerous lesions and OSCC. 2015;20(2). doi:10.4317/medoral.20368
Zeljic K, Supic G, Radak MS, Jovic N, Kozomara R. Vitamin D receptor , CYP27B1 and CYP24A1 genes polymorphisms association with oral cancer risk and survival. 2012. doi:10.1111/j.1600-0714.2012.01164.x
Tran HUY, Pant R, Adams JS, Mallya SM. Vitamin D signaling regulates oral keratinocyte proliferation in vitro and in vivo. 2014;(11):1625-1633. doi:10.3892/ijo.2014.2338
Sundaram K, Sambandam Y. 1 α , 25-Dihydroxyvitamin D3 Modulates CYP2R1 Gene Expression in Human Oral Squamous Cell Carcinoma Tumor Cells. 2014;3. doi:10.1007/s12672-014-0170-5
Trump, Donald L, Deeb, Kristen, Johnson CS. Vitamin d: Considerations in the Continued Development as an Agent for Cancer Prevention and Therapy. 2010:1-9.
Adeyemi OM, Agniel D, French AL, et al. Vitamin D Deficiency in HIV-Infected and HIV-Uninfected Women in the United States. Jaids-Journal Acquir Immune Defic Syndr. 2011;57(3):197-204. doi:10.1097/QAI.0b013e31821ae418
Kotikangas HO, Schwab U, Pia O. High Prevalence of Vitamin D Insufficiency in Patients with Head and Neck Cancer at Diagnosis. 2012:1-7. doi:10.1002/hed
Yokosawa EB, Arthur AE, Rentschler KM, Wolf GT, Rozek LS, Mondul AM. Vitamin D Intake and Survival and Recurrence in Head and Neck Cancer Patients. 2018;25:1-6. doi:10.1002/lary.27256
Fleet JC. Molecular Actions of Vitamin D Con tributing to Cancer Prevention. Mol Asp Med. 2008;29(6):388-396. doi:10.1016/j. mam.2008.07.003.Molecular
Roh J, Park J, Park C Il. Prevention of Postoperative Hypocalcemia With Routine Oral Calcium and Vitamin d Supplements in Patients With Differentiated Papillary Thyroid Carcinoma Undergoing Total Thyroidectomy Plus Central Neck Dissection. 2009. doi:10.1002/cncr.24027
Walsh, Jarret E et al. Use of Alpha, 25 Dihydroxyvitamin D3 Treatment to Stimulate Immune Infiltration Into Head and Neck Squamous Cell Carcinoma. Hum Immunol. 2010;71(7):659-665. doi:10.1016/j.humimm.2010.04.008.Use
Wang L, Wang C, Wang J, Huang X, Cheng Y. Longitudinal , observational study on associations between postoperative nutritional vitamin D supplementation and clinical outcomes in esophageal cancer patients undergoing esophagectomy. Nat Publ Gr. 2016;(August):1-10. doi:10.1038/srep38962
Xu W, Adjei A, Bairati I, Liu G, Douville P. Dietary vitamin D intake and serum 25-hydroxyvitamin D level in relation to disease outcomes in head and neck cancer patients. doi:10.1002/ijc.25496
Lipworth L, Rossi M, Mclaughlin JK, et al. original article Dietary vitamin D and cancers of the oral cavity and esophagus. 2009:1576-1581. doi:10.1093/annonc/mdp036
Holick MF, Chen TC. Vitamin D defciency: a worldwide problem with health consequences. Am J Clin Nutr. 2008;87(4):1080S-6S. doi:87/4/1080S [pii]
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
This work is licensed under a Creative Commons Attribution 4.0 International License.
