the effect of ozonated olive oil on the number of neutrophil cells in the gingiva of male Wistar rats experiencing periodontitis (in vivo)

Authors

  • Aprilia Yuanita Anwaristi universitas muhammadiyah surakarta
  • Cahyani Cahyani Universitas Muhammadiyah Surakarta
  • Ariyani Faizah Universitas Muhammadiyah Surakarta
  • Nida Faradisa Fauziyah Universitas Muhammadiyah Surakarta
  • Dani Fajar Arifin Universitas Muhammadiyah Surakarta
  • Nur Hidayanti Universitas Muhammadiyah Surakarta
  • Cindy Lestari Univeristas Muhammadiyah Surakarta

DOI:

https://doi.org/10.30659/odj.11.1.21-29

Keywords:

Periodontitis, Ozonated Olive Oil, Neutrophil

Abstract

Background: Periodontal tissue, comprising gingiva, periodontal ligament, cementum, and alveolar bone, supports and surrounds teeth. Periodontitis, an inflammation affecting these tissues, manifests through gingival inflammation, pocket formation, and loss of attachment and bone.

Purpose: This research aims to investigate whether ozonated olive oil influences neutrophil cell levels in the gingiva of male Wistar rats with periodontitis.

Method: Employing a posttest-only control group design, this laboratory study included 24 male Wistar rats with concentrated periodontitis divided into six groups based on the day of observation. Histological analysis was conducted on days 1, 3, and 5, with three control groups and treatment groups.

Result: The hypothesis test revealed a significant difference in neutrophil cell count between the ozonated olive oil treatment group and the control group (p < 0.05). The treatment group exhibited superior outcomes compared to control and other treatment groups, as confirmed by the LSD Post Hoc Test (p < 0.05).

Conclusion: Administration of ozonated olive oil can influence neutrophil cell involvement in periodontitis healing among male Wistar rats, suggesting its potential therapeutic efficacy

Author Biographies

  • Aprilia Yuanita Anwaristi, universitas muhammadiyah surakarta
    Periodontolofy Department
  • Cahyani Cahyani, Universitas Muhammadiyah Surakarta
    conservative department
  • Ariyani Faizah, Universitas Muhammadiyah Surakarta
    periodontology department
  • Nida Faradisa Fauziyah, Universitas Muhammadiyah Surakarta
    Public Health

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Published

2025-12-18

Issue

Vol. 11 No. 1 (2024): July 2024

Section

Original Article

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