Age <18 years, malnutrition and immunosupression therapy: Risk factors for bloodstream infection caused by Coagulase Negative Staphylococci (CoNS)

Nia Krisniawati  -  Universitas Jenderal Soedirman Purwokerto, Indonesia
Vincentia Rizke Ciptaningtyas*  -  Department of Clinical Microbiology, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia
Winarto Reki  -  Department of Clinical Microbiology, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

(*) Corresponding Author

Most blood culture contaminants are coagulase-negative staphylococci (CoNS), which are also the leading cause of nosocomial bloodstream infections. To date, no research in Indonesia has analyzed the potential causes of a CoNS infection in the bloodstream. The goal of this research was to better understand who is at risk for developing a CONS-related bloodstream infection while in a hospital setting. Secondary data from the CONS blood culture results at Dr. Kariadi Hospital Semarang were used in this retrospective cross-sectional study conducted between January 1 and December 31, 2016. The Vitek-2 Compact System (Biomerieux, USA) and the Kirby Bauer method (Clinical & Laboratory Standards Institute (CLSI) of the USA) were used for the antibiotic identification and sensitivity testing, respectively. Multivariate with multiple logistic regressions and the Chi-Square test for categorical variables were used in the analysis. Among the study's 272 participants, 158 (58.1%) developed CONS-related bloodstream infections. Risk factors for central nervous system (CNS) bloodstream infection in 18-year-olds include preterm birth, low birth weight (LBW), compromised immunity, malnutrition, immunosuppressive therapy, and peripheral intravenous use. Age >=18, malnutrition, and immunosuppression therapy all ranked high as risk factors in a multivariate analysis. Risk factors for CONS-causing bloodstream infections in people aged 18 include malnutrition and immunosuppressant therapy.

Keywords: Risk Factors; Coagulase Negative Staphylococci (CoNS); Multivariate; Bivariate;

  1. Becker, K., Heilmann, C. and Peters, G. (2014). Coagulase-negative staphylococci. Clinical Microbiology Reviews. American Society for Microbiology, 27(4): 870-926. doi: 10.1128/CMR.00109-13.
  2. Bizzarro, M.J, Shabanova, V., Baltimore, RS., Dembry, LM., Ehrenkranz, RA., Gallagher, PG. (2015). Neonatal sepsis 2004-2013: The rise and fall of coagulase-negative Staphylococci. Journal of Pediatrics. 2013(5): 1-5. doi: 10.1016/j.jpeds.2015.02.009.
  3. De Oliveira, A., Sanches, P., Lyra, João C., Bentlin, M.R., Rugolo, L.M.S.S, De Lourdes Ribeiro De Souza Da Cunha, Maria. (2012) Risk Factors for Infection with Coagulase-Negative Staphylococci in Newborns from the Neonatal Unit of a Brazilian University Hospital. Clinical Medicine Insights 15(6): 1-9. doi: 10.4137/cmped.s7427.
  4. Dudeck, MA., Weiner, LM., Allen-Bridson, K., Malpiedi, PJ., Peterson, KD., Pollock, DA., Sievert, DM., Edwards, JR. (2013). National Healthcare Safety Network (NHSN) report, data summary for 2012, Device-associated module. American Journal of Infection Control 41(12): 1148-66. doi: 10.1016/j.ajic.2013.09.002.
  5. Elzi, L., Babouee, B., Vögeli N., Laffer, R., Dangel, M., Frei, R., Battegay, M., Widmer, AF. How to discriminate contamination from bloodstream infection due to coagulase-negative staphylococci: A prospective study with 654 patients. Clinical Microbiology and Infection 18(9): E355-6. doi: 10.1111/j.1469-0691.2012.03964.x.
  6. Jones, K. D., and Berkley, J. A. (2014). Severe acute malnutrition and infection. Paediatrics and international child health, 34(Suppl 1): S1–S29. doi: 10.1179/2046904714Z.000000000218.
  7. Karakullukçu, A., Kuşkucu, M. A., Ergin, S., Aygün, G., Midilli, K., Küçükbasmaci, Ö. (2017) Determination of clinical significance of coagulase-negative staphylococci in blood cultures. Diagnostic Microbiology and Infectious Disease 87(3): 291-294. doi:10.1016/j.diagmicrobio.2016.12.006.
  8. Kirn, T. J. and Weinstein, M. P. (2013). Update on blood cultures: How to obtain, process, report, and interpret, Clinical Microbiology and Infection 19(6): 513-20. doi: 10.1111/1469-0691.12180.
  9. Marchant, E. A., Boyce, G. K., Sadarangani, M., Lavoie, P.M. (2013). Neonatal sepsis due to coagulase-negative Staphylococci. Clinical and Developmental Immunology 2013(5): 1-5. doi: 10.1155/2013/586076
  10. Montassier, E., Batard, E., Gastinne, T., Potel, G., de La Cochetière, M F. (2013). Recent changes in bacteremia in patients with cancer: A systematic review of epidemiology and antibiotic resistance. European Journal of Clinical Microbiology and Infectious Diseases 32(7): 841-50. doi: 10.1007/s10096-013-1819-7.
  11. Nguyen, T. H., Park, M. D. and Otto, M. (2017). Host response to Staphylococcus epidermidis colonization and infections. Frontiers in Cellular and Infection Microbiology 7(90): 1-5. doi: 10.3389/fcimb.2017.00090.
  12. Ozkan, H., Cetinkaya, M., Koksal, N., Celebi, S. and Hacımustafaoglu, M. (2014). Culture-proven neonatal sepsis in preterm infants in a neonatal intensive care unit over a 7 year period: Coagulase-negative Staphylococcus as the predominant pathogen. Pediatrics International 56(1): 60-66. doi: 10.1111/ped.12218.
  13. Soeorg H, Huik K, Parm U, Ilmoja ML, Metelskaja N, Metsvaht T, Lutsar I. (2013). Genetic relatedness of coagulase-negative staphylococci from gastrointestinal tract and blood of preterm neonates with late-onset sepsis. Pediatric Infectious Disease Journal 32(4): 389-93. doi: 10.1097/INF.0b013e3182791abd. PMID: 23080292.

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ISSN: 2339-093X (Online) | 2085-1545 (Print)
DOI : 10.30659/sainsmed

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