The Trial on the Effectiveness of Honey on White Rats Using Geliate Acetate Method An Experimental Study in Male Wistar Rat

Authors

  • Edijanti Goenarwo Bagian Farmakologi Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA)
  • Chodidjah Chodidjah Bagian Anatomi Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA)
  • Heri Susanto Mahasiswa Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA)

DOI:

https://doi.org/10.30659/sainsmed.v3i1.408

Keywords:

pain, honey, acetic acid

Abstract

Background: Pain is the most common complaint of a disease that can be reduced using the analgesic drugs. Besides the pharmacological medication, the traditional medications are available including honey containing flavanoid. The compound can protect the lipid membrane from the damage and inhibit cyclooxygenase, the main path of the synthesis mediator for pain like prostaglandin. This study aims at finding out the efficacy of analgesic of honey using geliate asetate method.

Design and methods: In an experimental study using post test only control group design, 25 Wistar rat (80-90 days, BW 180-220 gr) were randomly divided into 3 groups of 5 mice each. Gp1: =aquadest (negative control), Gp2: 0.675 g/BW honey, Gp3: 1.35g honey Gr 4: 2.7 g/kgBW honey and Gr 5 (possitive control): 4.5 mg/ BW of paracetamol. 5 minutes after the treatment, an intraperitoneal injection of acetic acid was given for all groups. Anova followed by post Hoc test was used for data analysis.

Result: The honey concentration of 50% (1.35) g was found to have increasing effect of analgesic while the concentration of 25% and 100 % showed a reducing analgesic effect.

Conclusion: Honey has been shown to have an analgesic effect in mice with the effective concentration of 50% (1.35 g/kgBW) (Sains Medika, 3(1):48-53).

Downloads

Published

2011-06-11

Issue

Vol. 3 No. 1 (2011): Januari-Juni 2011

Section

Original Research Articles

License

Journal Author(s) Rights

To publish and disseminate research articles, Sains Medika: Jurnal Kedokteran dan Kesehatan requires non-exclusive publishing rights (transferred from author(s) to publisher). This is determined by a publishing agreement between the Author(s) and Sains Med. J. Kedokt. dan Kesehat. This agreement governs with the transfer or license of the copyright of publishing to Sains Med. J. Kedokt. dan Kesehat, while Authors still retain significant rights to use and share their own published articles. Sains Med. J. Kedokt. dan Kesehat supports the need for authors to share, disseminate and maximize the impact of their research and these rights, in any databases.

As a journal Author, you have rights for a wide variety of uses of your article, including use by your institution or company of employment. These Author rights can be exercised without the need to obtain specific permission. Authors publishing in Sains Med. J. Kedokt. dan Kesehat have wide rights to use their works for teaching and scholarly purposes without needing to seek permission, including:

  1. Use for classroom teaching by Author or Author's institution and presentation at a meeting or conference and distributing copies to attendees; 
  2. Use for internal training by author's company; 
  3. Distribution to colleagues for their research use; 
  4. Use in a subsequent compilation of the author's works; 
  5. Inclusion in a thesis or dissertation; 
  6. Reuse of portions or extracts from the article in other works (with full acknowledgement of final article); 
  7. Preparation of derivative works (other than commercial purposes) (with full acknowledgement of final article); 
  8. Voluntary posting on open web sites operated by author or author's institution for scholarly purposes, 

Authors/Readers/Third Parties can copy and redistribute the material in any medium or format, as well as remix, transform, and build upon the material for any purpose, including commercial purposes, but they must give appropriate credit (the name of the creator and attribution parties (authors detail information), a copyright notice, an open access license notice, a disclaimer notice, and a link to the material), provide a link to the license, and indicate if changes were made (Publisher indicates the modification of the material (if any) and retain an indication of previous modifications using a CrossMark Policy and information about Erratum-Corrigendum notification).

Authors/Readers/Third Parties can read, print and download, redistribute or republish the article (e.g. display in a repository), translate the article, download for text and data mining purposes, reuse portions or extracts from the article in other works, sell or re-use for commercial purposes, remix, transform, or build upon the material, they must distribute their contributions under the same license as the original Creative Commons Attribution (CC BY).

Copyright Transfer Agreement for Publishing (Publishing Right)

The Authors submitting a manuscript do so on the understanding that if accepted for publication, the non-exclusive right for publishing (publishing right) of the article shall be assigned/transferred to the Publisher of Sains Medika: Jurnal Kedokteran dan Kesehatan and Faculty of Medicine Universitas Islam Sultan Agung (FK UNISSULA).

Upon acceptance of an article, authors will be required to complete a 'Copyright Transfer Agreement for Publishing (CTAP)'. An e-mail will be sent to the Corresponding Author confirming receipt of the manuscript together with a 'Copyright Transfer Agreement for Publishing' form by online version of this agreement.

Sains Medika: Jurnal Kedokteran dan Kesehatan and Faculty of Medicine Universitas Islam Sultan Agung (FK UNISSULA), the Editors and the Advisory International Editorial Board make every effort to ensure that incorrect or misleading data, opinions or statements be published in the journal. In any way, the contents of the articles and advertisements published in the Sains Medika: Jurnal Kedokteran dan Kesehatan are sole and exclusive responsibility of their respective authors and advertisers.

Remember, even though we ask for a transfer of copyright for publishing (CTAP), our journal Author(s) retain (or are granted back) significant scholarly rights as mentioned before.

The Copyright Transfer Agreement for Publishing (CTAP) Form can be downloaded here: [Copyright Transfer Agreement for Publishing (CTAP) Form Sains Medika 2022]


The copyright form must be electronically signed and emailed to the Editorial Office in the original form below: 

Dr. Suparmi, S.Si, M.Si (ERT) (Editor-in-Chief)
Editorial Office of Sains Medika: Jurnal Kedokteran dan Kesehatan
Gedung Dekanat Lantai 1 Fakultas Kedokteran Universitas Islam Sultan Agung

Jl. Raya Kaligawe KM 4 Semarang 50112, Central Java, Indonesia

Telp/Whatsapp: +62 812-2993-3369
E-mail: sainsmedika@unissula.ac.id

(This policy statements has been updated 19 October 2022)

What is Crossmark?

CrossMark, a multi-publisher initiative from CrossRef, provides a standard way for readers to locate the authoritative version of a document. Sains Medika: Jurnal Kedokteran dan Kesehatan acknowledges the significance of the integrity and completeness of the scholarly record to scholars and librarians, and places the utmost importance on preserving the credibility of its electronic archive. Clicking on the CrossMark icon will inform the reader of a document's current status and may provide additional publication record information.