Factors influencing infections caused by Extended Spectrum Beta Lactamase (ESBL) producing bacteria in patients with urinary tract infections at RSUD dr. R. Soetijono Blora

Authors

Published 2023-06-16
Issue Vol. 14 No. 1 (2023): June 2023
Section Original Research Articles
DOI: https://doi.org/10.30659/sainsmed.v14i1.31066
Keywords: UTI, Enterobacterales Extended Spectrum Beta Lactamase (ESBL)

Abstract

Urinary tract infection (UTI) is a bacterial infection that is often found in pediatric patients. The prevalence of infections due to ESBL-producing Enterobacterales is increasing worldwide. This study aims to identify and analyze the factors that influence Extended Spectrum Beta Lactamase (ESBL) producing bacteria in UTI patients at RSUD dr. R. Soetijono Blora. A cross-sectional study has been carried out at RSUD dr. R. Soetijono Blora in January-March 2023. The results of this study showed that 58 respondents with urine culture results found Enterobacterales pathogenic bacteria. Based on the sensitivity test for the Extended Spectrum Beta Lactamase (ESBL) enzyme producer, 39 people (67.2%) were categorized as ESBLs and 19 people (32.8%) Non-ESBLs. The study variables included age, gender, history of catheter insertion, history of stones or urinary tract surgery and history of taking antibiotics in the last 6 months. The chi-square test to determine the relationship between variables was used to determine significant risk factors. Bivariate logistic regression showed that history of catheter insertion and history of use of antibiotics in the last 6 months were significant risk factors. Prevalence of UTIs due to ESBL-producing Enterobacterales in RSUD dr. R. Soetijono Blora is high and the wise use of antibiotics, especially the third generation cephalosporins as therapy, is needed for preventive strategies to reduce antibiotic resistance

Downloads

Download data is not yet available.

Author Biographies

  • Endrawati Endrawati, Diponegoro University

    Master of Epidemiology, Postgraduate School, Diponegoro University, Semarang, Indonesia

  • Dwi Sutiningsih, Diponegoro University

    1 Master of Epidemiology, Postgraduate School, Diponegoro University, Semarang, Indonesia

    2Epidemiology and Tropical Disease Departement, Public Health Faculty, Diponegoro University, Semarang, Indonesia 

  • Mateus SA, Diponegoro University

    2Epidemiology and Tropical Disease Departement, Public Health Faculty, Diponegoro University, Semarang, Indonesia

License

Creative Commons License

© 2023 Author(s). Published by Sains Medika: Jurnal Kedokteran dan Kesehatan. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Endrawati, E., Sutiningsih, D., & SA, M. (2023). Factors influencing infections caused by Extended Spectrum Beta Lactamase (ESBL) producing bacteria in patients with urinary tract infections at RSUD dr. R. Soetijono Blora. Sains Medika: Jurnal Kedokteran Dan Kesehatan, 14(1), 13-19. https://doi.org/10.30659/sainsmed.v14i1.31066

References

Aboumarzouk. (2014). Extended-spectrum betalactamase urinary tract infections. Urology Annals, 6(2). www.urologyannals.com

Al-Jamei, S. A., Albsoul, A. Y., Bakri, F. G., & Al-Bakri, A. G. (2019). Extended-spectrum b-lactamase producing E. coli in urinary tract infections: A two-center, cross-sectional study of prevalence, genotypes and risk factors in Amman, Jordan. Journal of Infection and Public Health, 12(1), 21–25. https://doi.org/10.1016/j.jiph.2018.07.01

Anggraini, W., Candra, T. M., Maimunah, S., & Sugihantoro, H. (2020). Evaluasi Kualitatif Penggunaan Antibiotik pada Pasien Infeksi Saluran Kemih dengan Metode Gyssens. KELUWIH: Jurnal Kesehatan Dan Kedokteran,2(1), 1–8. https://doi.org/10.24123/kesdok.v2i1.2876

Biutifasari, V. (2018). Extended Spectrum Beta-Lactamase (ESBL). Oceana Biomedicina Journal,1. www.wiley.com

Dhillon, R. H. P.,& Clark, J. (2012). ESBLs: A clear and present danger? In Critical Care Research and Practice (Vol. 2012). https://doi.org/10.1155/2012/625170

Flokas, M. E., Karanika, S., Alevizakos, M., & Mylonakis, E. (2017). Prevalence of ESBL-producing Enterobacteriaceae in pediatric bloodstream infections: A systematic review and meta-analysis. Plos One, 12(1). https://doi.org/10.1371/journal.pone.0171216

Goyal, D., Dean, N., Neill, S., Jones, P., & Dascomb, K. (2019). Risk factors for community-acquired extended-spectrum beta-lactamase-producing Enterobacteriaceae infections-a retrospective study of symptomatic urinary tract infections. Open Forum Infectious Diseases, 6(2). https://doi.org/10.1093/ofid/ofy357

Harinda, L. (2022). Prevalensi dan Faktor Risiko Infeksi Saluran Kemih Akibat Enterobacterales Penghasil Beta Laktamase Spektrum Luas Pada Pasien Anak di RSUP Dr Kariadi Semarang.

Hebert, C., Gao, Y., Rahman, P., Courtney,;, Dewart, M., Shah, N., Lustberg, Mark, Stevenson, K., Pancholi, Preeti, Hade, E., Zhu, F., Maria, R.,Asmar, Basim, Salimnia, H., Thomas, R., Nahed,;, Abdel-Haq, M., Bukhari, A., Villacis Nunez, D. S., ... Laufer, M. (2019). Extended-Spectrum b-Lactamase (ESBL) Producing Escherichia coli in Children: A Case-Control Study. OFID, 6. https://academic.oup.com/ofid/article/6/Supplement_2/S523/5605826

Hu, Y., Wang, X., Tucker, J. D., Little, P., Moore, M., Fukuda, K., & Zhou, X. (2018). Knowledge, attitude, and practice concerning antibiotic use among Chinese medical students: A multicentre cross-sectional study. International Journal of Environmental Research and Public Health, 15(6). https://doi.org/10.3390/ijerph15061165

Killgore, K. M., March, K. L., & Guglielmo, B. J. (2004). Risk factors for community-acquired ciprofloxacin-resistant Escherichia coli urinary tract infection. In Annals of Pharmacotherapy (Vol. 38, Issues 7–8, pp. 1148–1152). https://doi.org/10.1345/aph.1D622

Koksal, E., Tulek, N., Sonmezer, M. C., Temocin, F., Bulut, C., Hatipoglu, C., Erdinc, F. S., & Ertem, G. (2019). Investigate risk factors for community-acquired urinary tract infections caused by extended-spectrum beta-lactamase Escherichia coli and Klebsiella species. Investigative and Clinical Urology, 60(1), 46-53. https://doi.org/10.4111/icu.2019.60.1.46

Larramendy, S., Deglaire, V., Dusollier, P., Fournier, J. P., Caillon, J., Beaudeau, F., & Moret, L. (2020). Risk factors of extended-spectrum beta-lactamases-producing escherichia coli community-acquired urinary tract infections: A systematic review. In Infection and Drug Resistance(Vol. 13, pp. 3945–3955). Dove Medical Press Ltd. https://doi.org/10.2147/IDR.S269033

Leung, A. K. C., Wong, A. H. C., Leung, A. A. M., & Hon, K. L. (2019). Urinary Tract Infection in Children. Recent Patents on Inflammation & Allergy Drug Discovery, 13(1), 2–18. https://doi.org/10.2174/1872213X13666181228154940

Luke Johnson, Allison Sabel MD, P. M. C., William J. Burman MD, Rachel M. Everhart MS, Marcie Rome, Thomas D. MacKenzie MD, M., Jeanne Rozwadowski MD, Philip S. Mehler MD, & Connie Savor Price MD. (2008). Emergence of Fluoroquinolone Resistance in Outpatient Urinary Escherichia coli Isolates. The American Journal of Medicine, 121(10), 876–884.

Magill, S. S., Edwards, J. R., Bamberg, W., Beldavs, Z. G., Dumyati, G., Kainer, M. A., Lynfield, R., Maloney, M., McAllister-Hollod, L., Nadle, J., Ray, S. M., Thompson, D. L., Wilson, L. E., & Fridkin, S. K. (2014). Multistate Point-Prevalence Survey of Health Care–Associated Infections. New England Journal of Medicine, 370(13), 1198–1208. https://doi.org/10.1056/nejmoa1306801

Mantu KFK, G. L. B. W. (2015). Evaluasi Penggunaan Antibiotik Pada Pasien Infeksi Saluran Kemih Di Instalasi Rawat Inap RSUP. Prof. DR. R. D. Kandou Manadoperiode Juli 2013 -Juni 2014. Pharmacon, 4.

Quan, J., Dai, H., Liao, W., Zhao, D., Shi, Q., Zhang, L., Shi, K., Akova, M., & Yu, Y. (2021). Etiology and prevalence of ESBLs in adult community-onset urinary tract infections in East China: A prospective multicenter study. Journal of Infection,83(2), 175–181. https://doi.org/10.1016/j.jinf.2021.06.004

Raz, R., Chazan, B., Kennes, Y., Colodner, R., Rottensterich, E., Dan, M., Lavi, I., & Stamm, W. (2002a). Empiric Use of Trimethoprim-Sulfamethoxazole (TMP-SMX) in the Treatment of Women with Uncomplicated Urinary Tract Infections in a Geographical Area with a High Prevalence of TMP-SMX-Resistant Uropathogens. In Clinical Infectious Diseases(Vol. 34). https://academic.oup.com/cid/article/34/9/1165/461822

Shah, P., Baral, R., Agrawal, C. S., Lamsal, M., Baral, D., & Khanal, B. (2020). Urinary Calculi: A Microbiological and Biochemical Analysis at a Tertiary Care Hospital in Eastern Nepal. International Journal of Microbiology, 2020. https://doi.org/10.1155/2020/8880403

Shakya, P., Shrestha, D., Maharjan, E., Sharma, V. K., & Paudyal, R. (2017). ESBL Production Among E. coli and Klebsiella spp. Causing Urinary Tract Infection: A Hospital Based Study. The Open Microbiology Journal, 11(1), 23–30. https://doi.org/10.2174/1874285801711010023

Sinatria L.R. (2019). Faktor Risiko Yang Mempengaruhi Terjadinya Bakteri Multiresisten. Universitas Islam Negeri Syarif Hidayatullah.

Winarto. (2009). Prevalensi Kuman ESBL(Extended Spectrum Beta Lactamase) dari Material Darah di RSUP Dr. Kariadi Tahun 2004-2005. Media Media Indonesiana, 43.