Prognostic significance of tumor angiogenesis markers in advanced cervical cancer undergoing chemotherapy

Authors

  • I Nyoman Bayu Mahendra Department of Obstetrics and Gynecology Prof. Dr. I.G.N.G. Ngoerah Central General Hospital, Denpasar, Bali
  • I Gde Sastra Winata Department of Obstetrics and Gynecology Prof. Dr. I.G.N.G. Ngoerah Central General Hospital, Denpasar, Bali
  • William Alexander Setiawan Department of Obstetrics and Gynecology Prof. Dr. I.G.N.G. Ngoerah Central General Hospital, Denpasar, Bali
  • Ida Bagus Agung Widnyana Putra Department of Obstetrics and Gynecology Prof. Dr. I.G.N.G. Ngoerah Central General Hospital, Denpasar, Bali
  • Putu Bagus Darmayasa Department of Obstetrics and Gynecology Prof. Dr. I.G.N.G. Ngoerah Central General Hospital, Denpasar, Bali
Published 2024-12-08
Issue Vol. 15 No. 2 (2024): December 2024
Section Review Articles
DOI: https://doi.org/10.30659/sainsmed.v15i2.28943
Keywords: advanced cervical cancer, chemotherapy, prognosis, VEGF, VEGFR

Abstract

Cervical cancer is the second leading cause of cancer-related deaths among women worldwide. Despite advancements in screening programs and vaccination efforts, a significant proportion of patients present with advanced-stage disease, characterized by severe manifestations and a poor prognosis. Clinical evidence highlights substantial variability in the sensitivity of chemotherapy regimens among cervical cancer patients, often resulting in suboptimal therapeutic outcomes and increased risk of complications. This underscores the need for reliable molecular markers to predict prognosis and optimize therapy. Angiogenesis plays a pivotal role in the development and progression of solid tumors, including cervical cancer. Key tumor angiogenesis markers, such as vascular endothelial growth factor (VEGF) and its receptor (VEGFR), are critical in driving tumor progression in advanced cervical cancer. Studies have demonstrated significant correlations between VEGF levels and important prognostic parameters, including tumor size, metastasis, and chemotherapy response. Consequently, tumor angiogenesis markers like VEGF and VEGFR hold potential as valuable predictive tools to guide the management of advanced cervical cancer, particularly in patients undergoing chemotherapy.

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Author Biographies

  • I Nyoman Bayu Mahendra, Department of Obstetrics and Gynecology Prof. Dr. I.G.N.G. Ngoerah Central General Hospital, Denpasar, Bali

    Department of Obstetrics and Gynecology Prof. Dr. I.G.N.G. Ngoerah Central General Hospital, Denpasar, Bali, Indonesia

  • I Gde Sastra Winata, Department of Obstetrics and Gynecology Prof. Dr. I.G.N.G. Ngoerah Central General Hospital, Denpasar, Bali
    Department of Obstetrics and Gynecology Prof. Dr. I.G.N.G. Ngoerah Central General Hospital, Denpasar, Bali, Indonesia
  • William Alexander Setiawan, Department of Obstetrics and Gynecology Prof. Dr. I.G.N.G. Ngoerah Central General Hospital, Denpasar, Bali
    Department of Obstetrics and Gynecology Prof. Dr. I.G.N.G. Ngoerah Central General Hospital, Denpasar, Bali, Indonesia
  • Ida Bagus Agung Widnyana Putra, Department of Obstetrics and Gynecology Prof. Dr. I.G.N.G. Ngoerah Central General Hospital, Denpasar, Bali
    Department of Obstetrics and Gynecology Prof. Dr. I.G.N.G. Ngoerah Central General Hospital, Denpasar, Bali, Indonesia
  • Putu Bagus Darmayasa, Department of Obstetrics and Gynecology Prof. Dr. I.G.N.G. Ngoerah Central General Hospital, Denpasar, Bali
    Department of Obstetrics and Gynecology Prof. Dr. I.G.N.G. Ngoerah Central General Hospital, Denpasar, Bali, Indonesia

License

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© 2024 Author(s). Published by Sains Medika: Jurnal Kedokteran dan Kesehatan. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Mahendra, I. N. B., Winata, I. G. S., Setiawan, W. A., Putra, I. B. A. W., & Darmayasa, P. B. (2024). Prognostic significance of tumor angiogenesis markers in advanced cervical cancer undergoing chemotherapy. Sains Medika: Jurnal Kedokteran Dan Kesehatan, 15(2), 88-95. https://doi.org/10.30659/sainsmed.v15i2.28943

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