Traditional herbal medicine for hyperuricemia: A review of randomized clinical trials

Authors

  • Arief Gunawan Darmanto Department of Biomedical Science, School of Medicine, Universitas Ciputra, Surabaya
  • Florence Pribadi Department of Biomedical Science, School of Medicine, Universitas Ciputra, Surabaya
  • Yoselyn Sucahyo School of Medicine, Universitas Ciputra, Surabaya
  • Arini Wiraputri School of Medicine, Universitas Ciputra, Surabaya
  • Della Mardhika School of Medicine, Universitas Ciputra, Surabaya
  • Christ Tambuang School of Medicine, Universitas Ciputra, Surabaya
  • Adinda Setiawan School of Medicine, Universitas Ciputra, Surabaya
  • Ummu Habibah School of Medicine, Universitas Ciputra, Surabaya
  • Kevin Luke Faculty of Medicine, Universitas Airlangga, Surabaya image/svg+xml
Published 2023-12-11
Issue Vol. 14 No. 2 (2023): December 2023
Section Review Articles
DOI: https://doi.org/10.30659/sainsmed.v14i2.23678
Keywords: Traditional chinese medicine, Medicinal plant, Hyperuricemia, Evidence-Based Medicine

Abstract

In the last decades, traditional herbal medicine for gout has been rapidly advanced. Numerous herbs have been identified for their hypouricidal effect. This review aims to explain the potential and mechanisms of traditional herbal medicine in reducing serum uric acid (sUA). This review included five RCTs and four traditional herbal medicine formulas from a previous systematic review. Articles published in non-English language were excluded for further analysis. Despite limited RCTs design, the formula of Chuanhu; Tufu, and ZinutriK® were beneficial for hyperuricemic individuals. While Yellow-dragon Wonderful-seed mixture showed limited hypouricemic feature. Based on these findings, traditional herbal medicine holds promising potential in treating hyperuricemia and gout. However, further studies are required.

Downloads

Download data is not yet available.

Author Biographies

  • Arief Gunawan Darmanto, Department of Biomedical Science, School of Medicine, Universitas Ciputra, Surabaya

    Department of Biomedical Science, School of Medicine, Universitas Ciputra, Surabaya, Indonesia

  • Florence Pribadi, Department of Biomedical Science, School of Medicine, Universitas Ciputra, Surabaya
    Department of Biomedical Science, School of Medicine, Universitas Ciputra, Surabaya, Indonesia
  • Yoselyn Sucahyo, School of Medicine, Universitas Ciputra, Surabaya
    School of Medicine, Universitas Ciputra, Surabaya, Indonesia
  • Arini Wiraputri, School of Medicine, Universitas Ciputra, Surabaya
    School of Medicine, Universitas Ciputra, Surabaya, Indonesia
  • Della Mardhika, School of Medicine, Universitas Ciputra, Surabaya
    School of Medicine, Universitas Ciputra, Surabaya, Indonesia
  • Christ Tambuang, School of Medicine, Universitas Ciputra, Surabaya
    School of Medicine, Universitas Ciputra, Surabaya, Indonesia
  • Adinda Setiawan, School of Medicine, Universitas Ciputra, Surabaya
    School of Medicine, Universitas Ciputra, Surabaya, Indonesia
  • Ummu Habibah, School of Medicine, Universitas Ciputra, Surabaya
    School of Medicine, Universitas Ciputra, Surabaya, Indonesia
  • Kevin Luke, Faculty of Medicine, Universitas Airlangga, Surabaya

    Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

License

Creative Commons License

© 2023 Author(s). Published by Sains Medika: Jurnal Kedokteran dan Kesehatan. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Darmanto, A. G., Pribadi, F., Sucahyo, Y., Wiraputri, A., Mardhika, D., Tambuang, C., Setiawan, A., Habibah, U., & Luke, K. (2023). Traditional herbal medicine for hyperuricemia: A review of randomized clinical trials. Sains Medika: Jurnal Kedokteran Dan Kesehatan, 14(2), 79-83. https://doi.org/10.30659/sainsmed.v14i2.23678

References

Chen, L. et al. (2021) ‘The Efficacy and Mechanism of Chinese Herbal Medicines in Lowering Serum Uric Acid Levels: A Systematic Review’, Frontiers in Pharmacology, 11(January). doi: 10.3389/fphar.2020.578318.

Haidari, F. et al. (2011) ‘Effects of parsley (Petroselinum crispum) and its flavonol constituents, kaempferol and quercetin, on serum uric acid levels, biomarkers of oxidative stress and liver xanthine oxidoreductase aactivity inoxonate-induced hyperuricemic rats’, Iranian Journal of Pharmaceutical Research, 10(4), pp. 811–819.

Hu, Q. H. et al. (2009) ‘Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: Renal organic ion transporter involvement’, American Journal of Physiology - Renal Physiology, 297(4), pp. 1080–1091. doi: 10.1152/ajprenal.90767.2008.

Huang, L. et al. (2019) ‘The anti-hyperuricemic effect of four astilbin stereoisomers in Smilax glabra on hyperuricemic mice’, Journal of Ethnopharmacology, 238(November 2018), p. 111777. doi: 10.1016/j.jep.2019.03.004.

Hyndman, D., Liu, S. and Miner, J. N. (2016) ‘Urate Handling in the Human Body’, Current Rheumatology Reports, 18(6). doi: 10.1007/s11926-016-0587-7.

Kong, L. D. et al. (2004) ‘A Chinese herbal medicine Ermiao wan reduces serum uric acid level and inhibits liver xanthine dehydrogenase and xanthine oxidase in mice’, Journal of Ethnopharmacology, 93(2–3), pp. 325–330. doi: 10.1016/J.JEP.2004.04.008.

Lin, X. et al. (2020) ‘Simiao Decoction Alleviates Gouty Arthritis by Modulating Proinflammatory Cytokines and the Gut Ecosystem’, Frontiers in Pharmacology, 11(June), pp. 1–13. doi: 10.3389/fphar.2020.00955.

Liu, Y. F. et al. (2017) ‘The Effects of Modified Simiao Decoction in the Treatment of Gouty Arthritis: A Systematic Review and Meta-Analysis’, Evidence-based Complementary and Alternative Medicine, 2017. doi: 10.1155/2017/6037037.

Lv, H. et al. (2019) ‘A Traditional Clinic Chinese Medicine Prescription Qu-Zhuo-Tong-Bi (QZTB) Alleviates Gouty Arthritis in Model Rats’, Evidence-based Complementary and Alternative Medicine, 2019. doi: 10.1155/2019/9456318.

Maiuolo, J. et al. (2016) ‘Regulation of uric acid metabolism and excretion’, International Journal of Cardiology, 213, pp. 8–14. doi: 10.1016/j.ijcard.2015.08.109.

Martillo, M. A., Nazzal, L. and Crittenden, D. B. (2014) ‘The crystallization of monosodium urate’, Current Rheumatology Reports, 16(2), pp. 1–13. doi: 10.1007/s11926-013-0400-9.

Meng, X. et al. (2017) ‘Baicalein decreases uric acid and prevents hyperuricemic nephropathy in mice’, Oncotarget, 8(25), pp. 40305–40317. Available at: www.impactjournals.com/oncotarget/.

El Ridi, R. and Tallima, H. (2017) ‘Physiological functions and pathogenic potential of uric acid: A review’, Journal of Advanced Research, 8(5), pp. 487–493. doi: 10.1016/j.jare.2017.03.003.

Rozza, F. et al. (2016) ‘Effects of a Novel Fixed Combination of Nutraceuticals on Serum Uric Acid Concentrations and the Lipid Profile in Asymptomatic Hyperuricemic Patients: Results from the PICONZ-UA Study’, High Blood Pressure and Cardiovascular Prevention, 23(4), pp. 381–386. doi: 10.1007/s40292-016-0168-x.

Wang, Y. G. et al. (2014) ‘Chuanhu anti-gout mixture versus colchicine for acute gouty arthritis: A randomized, Double-Blind, Double-Dummy, Non-Inferiority Trial’, International Journal of Medical Sciences, 11(9), pp. 880–885. doi: 10.7150/ijms.9165.

Wang, Yao et al. (2019) ‘A Randomized Controlled Trial of Chuanhutongfeng Mixture for the Treatment of Chronic Gouty Arthritis by Regulating miRNAs’, Evidence-based Complementary and Alternative Medicine, 2019. doi: 10.1155/2019/5917269.

Wen, X. et al. (2021) ‘Qu-Zhuo-Tong-Bi Decoction Alleviates Gouty Arthritis by Regulating Butyrate-Producing Bacteria in Mice’, Frontiers in Pharmacology, 11(February), pp. 1–15. doi: 10.3389/fphar.2020.610556.

Xie, Z. et al. (2017) ‘Hypouricemic and arthritis relapse-reducing effects of compound tufuling oral-liquid in intercritical and chronic gout’, Medicine (United States), 96(11), pp. 1–9. doi: 10.1097/MD.0000000000006315.

Xu, H. et al. (2022) ‘Network pharmacology and in vivo experiments reveal the pharmacological effects and molecular mechanisms of Simiao Powder in prevention and treatment for gout’, BMC Complementary Medicine and Therapies, 22(1), pp. 1–17. doi: 10.1186/s12906-022-03622-0.

You, W. et al. (2019) ‘Modified Chuanhu anti-gout mixture, a traditional Chinese medicine, protects against potassium oxonate-induced hyperuricemia and renal dysfunction in mice’, Journal of International Medical Research, 47(5), pp. 1927–1935. doi: 10.1177/0300060519831182.

Yu, X. N. et al. (2018) ‘“Yellow-dragon Wonderful-seed Formula†for hyperuricemia in gout patients with dampness-heat pouring downward pattern: A pilot randomized controlled trial’, Trials, 19(1), pp. 1–10. doi: 10.1186/s13063-018-2917-8.

Zhou, X. et al. (2021) ‘Chlorogenic acid supplementation ameliorates hyperuricemia, relieves renal inflammation, and modulates intestinal homeostasis’, Food and Function, 12(12), pp. 5637–5649. doi: 10.1039/d0fo03199b.