Potential therapy of umbilical cord mesenchymal stem cells (UC-MSC) in renal fibrosis

Authors

Published 2023-06-07
Issue Vol. 14 No. 1 (2023): June 2023
Section Review Articles
DOI: https://doi.org/10.30659/sainsmed.v14i1.22458
Keywords: chronic kidney disease, acute kidney injury, unilateral ureteral obstruction.

Abstract

Renal fibrosis (RF) is a severe kidney pathology defined by myofibroblast anomalies that create extracellular material on the interstitial and glomerular surfaces. The current therapy for treating renal disease has not achieved excellent results. A new theory about applying umbilical cord mesenchymal stem cells (UC-MSC) to treat renal fibrosis and other fibrosis-affected organs has been developed. This review aims to elucidate the role of UC-MSC in the therapy of renal fibrosis and summarize the numerous biological mechanisms involved. A search was undertaken using PubMed and Google Scholar from 2003 to 2021 to gather information regarding the Potential therapy with UC-MSC in renal fibrosis. Multiple studies on rat models of renal fibrosis have demonstrated a considerable improvement in fibrotic kidneys following UC-MSC treatment. It can transfer functional proteins and genetic information to recipient cells that suppress the fibrosis process. UC-MSC is considered a superior approach to MSC for therapeutic purposes due to its straightforward collection, minimum immunogenicity, and solid paracrine potency. The UC-MSC cellular treatment for renal impairment is a feasible option in the future.

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Author Biographies

  • Evi Lusiana, Department of Pharmacology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia

    Department of Pharmacology, Faculty of Medicine, Universitas Sriwijaya, Palembang

  • Legiran Legiran, Department of Biomedicine, Faculty of Medicine, Universitas Sriwijaya, Palembang

    Department of Biomedicine, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia

License

Creative Commons License

© 2023 Author(s). Published by Sains Medika: Jurnal Kedokteran dan Kesehatan. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Lusiana, E., & Legiran, L. (2023). Potential therapy of umbilical cord mesenchymal stem cells (UC-MSC) in renal fibrosis. Sains Medika: Jurnal Kedokteran Dan Kesehatan, 14(1), 28-34. https://doi.org/10.30659/sainsmed.v14i1.22458

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