EFFECT OF TEA TREE (MELALEUCA ALTERNIFOLIA) GEL ON FIBROBLASTS, BLOOD VESSELS AND COLLAGEN POST-EXODONTICS
DOI:
https://doi.org/10.30659/medali.7.2.126-135Keywords:
Tea Tree, Exodontia, Fibroblast, collagen, blood vesselsAbstract
Background: Dental exodontics cause wounds to the surrounding tissue where the exodontic procedure was performed. The wound healing process is influenced by the formation of new blood vessels, fibroblast and collagen. Tea-tree has anti-inflammatory and antibacterial properties that can support the wound healing process. Objective: This study aims to determine the effect of tea tree get application on the number of blood vessel cells, fibroblasts, and collagen in post-exodontic sockets of male wistar rats. Research Methods: This study use a true experimental laboratories design with a post test - only control group design with a sample of 27 male Wistar rats which were divided into 9 groups, each group of which had 3 male Wistar rats and then added a reserve of 1 head of each group so the total sample and the reserve amounted to 36 heads. Exodontics were performed on the maxillary left central incisor to facilitate field view and reduce the risk of rat death. The concentration of tea tree gel used was 5%. The number of blood vessel cells, fibroblast and collagen density were observed and counted on days 3, 5 and 7 then the average was taken. Result: the result showed that the mean number of fibroblast cells, blood vessels and collagen density increased from day 3,5 and 7. Conclusion: it can be shown that the application of tea tree gel can increase fibroblast cells, blood vessels and collagen density in post-exodontic socket of male Wistar rats, thus accelerating the wound healing process.
References
Abdel Aziz D, Abou Khadr M, Mahmoud S, Taalab M, Elmoslemany R. Mangement of Moderate Periodontitis By Using of Tea Tree Oil: a Randomized Controlled Clinical Trial. Alexandria Dent J. 2022;0(0):0–0.
Ardiana T, Rizkia A, Kusuma P, Firdausy MD. Efektivitas Daun Jambu Biji Terhadap Jumlah Sel Fibroblas Pasca Luka Pencabutan Gigi Pada Marmut (Cavia Cobaya). ODONTO Dent J. 2015;2:64–70
Balaji S, Balaji PP. Textbook of oral & maxillofacial surgery. 4th ed. Elsevier Inc; 2023.
Bharadwaj AN, Byatappa V, Raju R, Umakanth R, Alayadan P. Antiplaque and antigingivitis effectiveness of tea tree oil and chlorine dioxide mouthwash among young adults: a randomized controlled trial. World J Dent. 2020;11(6):451-6.
Budi HS, Soesilowati P, Imanina Z. Gambaran histopatologi penyembuhan luka pencabutan gigi pada makrofag dan neovaskular dengan pemberian getah batang pisang ambon. Maj Kedokt Gigi Indones. 2017;3(3):121–7.
Fredella MD, Rahman OA, Miftahurrahmah. Perbandingan daya hambat minyak atsiri green tea dan tea tree terhadap bakteri Staphylococcus aureus. J Med Stud. 2022;2(1):68–75.
Furqoni A, Amin NM, Prasetya CR. Potensi kombinasi scaffold gipsum Puger dan Aloe vera terhadap angiogenesis pada soket pasca ekstraksi gigi. Padjadjaran J Dent Res Stud. 2022;6(1):82–9.
Lestari N, Lauddin T, Amir AMIM. Indikasi dan Kontraindikasi Pencabutan Gigi. DENThalib J. 2023;1(3):73–9.
Mardiyantoro F, Khusnul M, Viranda S, Miftakhul C, Ariyati P. Penyembuhan luka rongga mulut. Universitas Brawijaya Press; 2018.
Mathew-Steiner SS, Roy S, Sen CK. Collagen in wound healing. Bioengineering. 2021;8(5).
Ningsih JR. Ilmu Dasar Kedokteran Gigi. University of Muhammadiyah Surakarta. 2018. 199–214 p.
Nofikasari I, Rufaida A, Aqmarina CD, Failasofia F, Fauzia AR, Handajani J. Efek aplikasi topikal gel ekstrak pandan wangi terhadap penyembuhan luka gingiva. Maj Kedokt Gigi Indones. 2016;2(2):53–9.
Nugraheni RW, Chasanah U. Penerapan desain eksperimen dalam optimasi formula mikroemulsi Tea Tree Oil. HERCLIPS J Herb Clin Pharm Sci. 2019;1(1):5–8.
Nugroho MA, Elfiah U, Normasari R. Pengaruh gel ekstrak dan serbuk mentimun (Cucumis sativus) terhadap angiogenesis pada penyembuhan luka bakar derajat IIB pada tikus Wistar. E-J Pustaka Kesehatan. 2016;4(3):443–8.
Panjaitan WYI, Telussa AS, Sihotang JS. Comparison of Siam werd leaf (Chromolaena odorata) extract and povidone iodine 10% to angiogenesis in incision wound in white mice (Sprague dawley). Cendana Med J. 2023;11(2):272–8.
Primadina N, Basori A, Perdanakusuma DS. Proses Penyembuhan Luka Ditinjau dari Aspek Mekanisme Seluler dan Molekuler. Qanun Med - Med J Fac Med Muhammadiyah Surabaya. 2019;3(1):31.
Ramadhany EP, Sukamlia M, Dewi RA. Effect of kecemcem tree (Spondias pinnata) bark extract gel to increase collagen post Wistar rats curettage. Interdental J Kedokt Gigi (IJKG). 2023;19(2):195–201.
Rao R, Jambheshwar G. A Promising Bioactive Component Terpinen-4-Ol: A Review. 2016;3(8):336–45.
Santosa AH, Kintawati S, Sugiaman VK. Effect of Resorbable Collagen Plug (RCP) on Extraction Wound Healing. e-GiGi. 2022 Mar 3;10(1):81.
Singh D, Rai V, K Agrawal D. Regulation of Collagen I and Collagen III in Tissue Injury and Regeneration. Cardiol Cardiovasc Med. 2023;07(01):5–16.
Sürme Y, Çürük GN, Lekesizcan A, Özdamar S. The Effect Of Tea Tree Oil On Wound Healing In Diabetic Rats. Wound Pract Res. 2022;30(2):91–8.
Tamuntuan DN, Queljoe E de, Datu OS. Uji Efektivitas Penyembuhan Luka Sediaan Salep Ekstrak Rumput Macan (Lantana camara L) Terhadap Luka Sayat Pada Tikus Putih Jantan (Rattus norvegicus). Pharmacon. 2021;10(3):1040–9.
Wahyuningsih S, Bachri N, Awaluddin N, Andriani I. Serum wajah fraksi etil asetat daun beluntas (Pluchea indica L.) sebagai antibakteri. J Katalisator. 2021;6(2):270–83.
Widyastuti AAGI. Ekstrak pasta ubi jalar ungu (Ipomoea batatas L.) mempercepat angiogenesis dan meningkatkan jumlah fibroblas soket mandibula pada penyembuhan luka pasca pencabutan gigi marmut jantan (Cavia cobaya). 2017.
Wijaya BA, Citraningtyas G, Wehantouw F. Potensi ekstrak etanol tangkai daun talas (Colocasia esculenta L) sebagai alternatif obat luka. J Ilm Farm. 2014;3(3):211–9.
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
This work is licensed under a Creative Commons Attribution 4.0 International License.
