Flavonoids and Aging

Taufiqurrachman Nasihun*  -  Biochemistry Department, Medical Faculty, Sultan Agung Islamic University, UUNISSULA, Semarang, Indonesia, Indonesia

(*) Corresponding Author
Aging is inevitable process, however human comes into aging is in difference way and difference rates. Some of them undergo aging earlier due to degenerative diseases, unable to reach the maximum lifespan and are thus denominated secondary aging (Huebschmann AG, 2011). Some of others undergo aging latter, looked younger than their truely chronological age, have no suffer degenerative disease, able to achieve maximum lifespan and so called primary aging (De la Fuente, 2009; Huebschmann AG, 2011). Maximum lifespan or often called longevity of the species is defined as maximum time that a species belonging to determine how long the species can live, for example maximum lifespan in human beings is 122 years, whereas the lifespan in rats and mouse strains is only 3 and 4 years respectively (De lafuente, 2009). It must be distinguished this longevity from mean or averages longevity. Average longevity can be defined as the average of time that member of population that have been born on the same date live (De la Fuente, 2009). The maximum lifespan is fixed in each species, meanwhile the lifespan of individual subject in the population, even when their genotype are the same and grow in a common environment condition, such as protected from external hazard show marked variability (Kirkwood, 2005).

Keywords: Flavonoids; Aging

  1. Chou CH, Hwang CL, Wu YT. 2012. Effect of Exercise on Physical Function, Daily Living Activities, and Quality of Life in the Frail Older Adults: A Meta-Analysis. Arch Phys Med Rehabil: 93: 237 – 44.
  2. De la Fuente M, Miquel J. 2009. An Update of the Oxidation-Inflammation Theory of Aging: The Involvement of the Immune System in Oxi-Inflamm-Aging. Current Pharmaceutical Design: 15, 3003-3026.
  3. Ferrie`res J. 2004. THE FRENCH PARADOX: LESSONS FOR OTHER COUNTRIES. Heart. 90:107–111.
  4. Fries JF. 1980. Aging, natural death, and the compression of morbidity. The New England Journal of Medicine 303: 130 – 35.
  5. Giovannini C, Masella R. 2011. Role of polyphenols in cell death control. Nutritional Neuroscience: 15, 134 – 47.
  6. Huebschmann AG, Kohrt WM, Regensteiner JG. 2011. Exercise attenuates the premature cardiovascular aging effects of type 2diabetes mellitus. Vascular Medicine 16 (5) 378 – 390.
  7. Kirkwood TBL, Feder M, Finch CE, Franceschi C, Globerson A, Klingenberg ChP, et al. 2005. What accounts for the Wide variation in life span of genetically identical organisms reared in a constant environment?. Mech Ageing Dev: 126: 439-43.
  8. Kosorok MR, Omenn GS, Diehr P, et al. 1992. Restricted activity days among older adults. Am J Public Health;82:1263-1267.
  9. Kumar S, Pandey AK. 2013. Chemistry and Biological Activities of Flavonoids: An Overview. The Scientific World Journal: 1 – 16.
  10. Kumar S, Gupta A, Pandey AK. 2013. “Calotropis procera root extract has capability to combat free radical mediated damage, ISRN Pharmacology.
  11. Mishra A, Kumar S, and Pandey AK. 2013. “Scientific validation of the medicinal efficacy of Tinospora cordifolia,†The Scientific World Journal, vol. 2013, Article ID 292934.
  12. Opie LH, Lecour S. 2007. The red wine hypothesis: from concepts to protective signalling molecules. European Heart Journal: 28, 1683–1693.
  13. Patil CS, Singh VP, Satyanarayan PSV, Jain NK, Singh A, Kulkarni SK. 2003.Protective Effect of Flavonoids against Aging- and Lipopolysaccharide-Induced Cognitive Impairment in Mice. Pharmacology 69:59–67.
  14. Peng C, Wang X, Chen J, Jiao R, Wang L, Li YM, Zuo Y. 2014. Biology of Ageing and Role of Dietary Antioxidants. BioMed Research International: 1 – 13.
  15. Syslová K, Böhmová A, Mikoška M, Kuzma M, Pelclová D, KaIer P. 2014. Multimarker Screening of Oxidative Stress in Aging. Oxidative Medicine and Cellular Longevity: 1 – 14.
  16. Watjen W, Michels G, steffan B, et al. 2005. Low concentration of Flavonoids are Protective in Rtas H411E cells, whreas high concentration cause DNA damage and apoptosis. The journal of Nutrition: 3: 525

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ISSN: 2339-093X (Online) | 2085-1545 (Print)
DOI : 10.30659/sainsmed

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