Effect of Jinten Hitam Seeds Oil (Nigella sativa L.) In adenocarsinoma Mammae C3H Mice In Vivo An Experimental Study on C3H Mice Inoculated With Cancerous Tissue

Agus Suprijono*  -  Bagian Patologi Anatomi Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA), Indonesia
Sumarno Sumarno  -  Bagian Patologi Anatomi Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA), Indonesia
Hanugalih Hanugalih  -  Mahasiswa Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA), Indonesia

(*) Corresponding Author
Background: Jinten hitam (Nigella sativa L.) oil is a liquid made from Jintem hitam seeds which has been known to contain Thymoquinone having anti-cancer efect. Many cancer patients turn to cheaper alternative therapy including the traditional therapy. The objective of this experimental was to evaluate anti-cancer effect of Jinten hitam seeds oil in adenocarsinoma mammae C3H mice.

Design and Methods: In this xperimental research with pre post test randomized control group design for 21 days, 24 C3H mice with tumor were divided into 4 group. K-I serves as a control given standard diet and aquades, K-II given standard diet, aquades and first dose of Jinten Hitam oil (0.1 ml/days), K-III given standard diet, aquades and second dose of Jinten Hitam oil ( 0.2 ml/days) and K-IV given standard diet, aquades and third dose of Jinten Hitam oil ( 0.3 ml/days). The volume was recorded at the day 21.

Results: mean of the effect of Jinten hitam oil effect in adenocarcinoma mammae for the four group were 158.83 mm³, 259.73 mm³, 191.13 mm³, K-IV 126.27 mm³ respectively. Pair t-test and Wilcoxon test showed significant difference between First dose pre-First dose post and Second dose pre-second dose-post (p<0.05) and Anova test showed no significant difference between K-I K-II, K-I K-III, K-I K-IV, K-II K-III, K-II K-IV, K-III K-IV (p>0.05).

Conclusion: Jinten Hitam oil has effect on the volume of Adenocarcinoma mammae in C3H mice (Sains Medika, 3(2):129-134).

Keywords : Jinten Hitam oil (Nigella sativa L.); adenocarcinoma mammae; volume.

Sains Medika : Jurnal Kedokteran dan Kesehatan
is published by Fakultas Kedokteran Universitas Islam Sultan Agung Semarang, Indonesia.
Jl. Raya Kaligawe Km.4, PO BOX 1054/SM Semarang 50112
Website: https://fkunissula.ac.id/
Email: sainsmedika@unissula.ac.id

ISSN: 2339-093X (Online) | 2085-1545 (Print)
DOI : 10.30659/sainsmed

This work is licensed under a [note] - Creative Commons Attribution 4.0 International License

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