Bagian Penyakit Dalam Fakultas Kedokteran Universitas Islam Sultan Agung Semarang - Indonesia
Fluid Balance, Interferon-Gamma, Interleukin- 12 and Tumor Necrosis as predictive factors of Survival in Severe Sepsis
Design and Method: Randomized Clinical Trials were conducted of 110 patients suffered from severe sepsis in ICU/HCU. Admission APACHE II, SOFA scores, IFN- , IL-12, TNF-Ã¡, and fluid balance were computed from the extracted data. Patients allowed to severe sepsis treatment according with the International Consensus Committee. Summary estimates using both the Mantel-Haenszel test and precision based approaches were computed for statistical analysis.
Result: Of 110 patients ranged in age from 46 to 71 years with a mean (Â± SE) age of 63.45 Â± 3.97 years. The mean admission APACHE II score was 25.96 Â± 3.65; and the day 1 SOFA score was 9.57 Â± 1.24. Twenty one patients did not survive, Non-survival had higher mean APACHE II than survivals (29.85 vs 20.46), respectively (p < 0.01). Higher first day IFN- , IL-12, TNF-Ã¡, and SOFA scores (p< 0.01). Whereas 26 patients who achieved a negative fluid balance of > 500 mL on > of the first 3 days of treatment survived (RR 5.0; 95% CI : 2.3 to 10.7, p < 0.0001).
Conclusion: These results suggest that at least 1 day of negative fluid balance (<-500mL), IFN- , IL-12, and TNF-Ã¡ may be a good independent predictors of survival in patients with severe sepsis. These findings suggest the hypothesis that four independent predictors of severe sepsis portend a good prognosis for a larger prospective study (Sains Medika, 4(1):13-22).
Keywords : kidney; multiple organ failure; severe sepsis; urine.
Metrics powered by PLOS ALM