EFFECT OF MANGOSTEEN PEEL EXTRACT ON SGOT AND SGPT IN RATS FED REUSED COOKING OIL

Esti Widyastuti, Nani Maharani, Astika Widy Utomo

Abstract


Background: Free radicals that enter the body due to consumption of reused cooking oil can cause liver cell damage. Mangosteen peel extract (Garcinia mangostana L) is known to contain mangostin as an antioxidant. However, it is not known whether it can repair liver damage. Objective: To determine the effect of mangosteen peel extract on the levels of SGOT and SGPT of Wistar rats fed with reused cooking oil.

Methods: This study was a true experimental study with post-test only controlled group design. Twenty four male Wistar rats were randomly divided into 4 groups randomly. The CN-G group was given the standard diet, the MJ-G group was given a standard diet and cooking oil, the MJM-400 group was given standard diet, reused cooking oil, and mangosteen peel extract at a dose of 400 mg/KgBW, and the MJM-800 group was fed with a standard, reused cooking oil, and mangosteen peel extract at 800mg/KgBW. The treatment was carried out for 28 days, and then continued with examination of SGOT and SGPT levels using the International Federation of Clinical Chemistry (IFCC) method without Pyridoxal Phosphate 37⁰C.

Results: Kruskal Walis test showed that SGOT and SGPT levels showed no significant differences between groups (p = 0.197 and 0.063, respectively).

Conclusion: administration of mangosteen (Garcinia mangostana L) peel extract did not affect SGOT levels, even tended to increase SGPT levels in rats induced by cooking oil.

Keywords: used cooking oil, mangosteen peel extract, SGOT levels, SGPT levels


Keywords


Minyak jelantah; ekstrak kulit manggis; kadar SGOT; kadar SGPT

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DOI: http://dx.doi.org/10.26532/sainsmed.v9i2.2286

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