The Effect of Moderate-Intensity Physical Exercise on Interleukin-6 Level and Lymphocyte Count in Leprosy Reaction Patient

Adryan Roy*  -  Medical Faculty of Sultan Agung Islamic University (UNISSULA) Jl. Raya Kaligawe Km.4 Semarang, PO.BOX 1054, 50112 Jawa Tengah, Indonesia
Taufiqurrachman Nasihun  -  Biochemistry Departement, Medical Faculty of Sultan Agung Islamic University, Semarang, Indonesia, Indonesia
Titiek Sumarawati  -  Chemistry Departement, Medical Faculty of Sultan Agung Islamic University, Semarang, Indonesia, Indonesia

(*) Corresponding Author
DOI: 10.30659/sainsmed.v12i1.11931

Introduction: Leprosy reaction is an immunity declining reaction marked with inflammation which may cause permanent disability. Physical exercise may improve body’s immune system. Objective: To prove the effect of moderate-intensity physical exercise on the interleukin-6 level and lymphocyte count in leprosy reaction patient.
Methods: The quasi-experimental research with pretest and posttest and a control group design used 30 respondents consisting of 14 interventions and 16 controls. The intervention group was given moderate-intensity physical exercise 60%-79% in the form of static cycle at a frequency of 4 times weekly, 150 minutes per week. Corticosteroid was always administered to the two groups as a standard therapy. The interleukin-6 level was measured using ELISA method and lymphocyte count was measured using hematology analyzer.
Result: The Mann-Whitney analysis shows that the mean difference in IL-6 level between pretest and posttest with the intervention group (-7.1429±25.2369) is significantly lower than that of the control group (8.8125±11.2025), p<0.05. On the contrary, the Independent t-test analysis shows that the mean difference in lymphocyte count between pretest and posttest with the intervention group (0.7407±0.41236) is significantly higher than that of the control group (-0.4500±0.42415), p<0.05.
Conclusion: Physical exercise at moderate intensity in the form of aerobics using static cycle at a frequency of 4 times weekly, with duration of 150 minutes per week decreases interleukin-6 level and increases lymphocyte count in leprosy reaction patient.

 

Keywords: moderate-intensity exercise; IL-6; lymphocyte

  1. Aditama, T. Y. (2012) Pedoman Nasional Program Pengendalian Penyakit Kusta. Jakarta: Direktorat Jendral Pengendalian Penyakit dan Penyehatan Lingkungan Kementerian Kesehatan RI.
  2. Afriwandi (2011) Ilmu Kedokteran Olahraga. Jakarta: EGC.
  3. Andini, F. et al. (2016) ‘Morbus Hansen Tipe Multibasiler dengan Reaksi Kusta Tipe 1 dan Kecacatan Tingkat 2’, J Medula Unila, 6(1), pp. 44–49.
  4. Aroziah, M., Sugiharto & and Kinanti, R. G. (2014) ‘Efek Latihan Terhadap Imonoglobulin (IgG) Pada Tikus Putih Wistar Norvegicus Strain’, Jurnal Sport Science, 4(3), pp. 125–129. Available at: http://journal.um.ac.id/index.php/sport-science/article/view/4918/1305.
  5. Bafirman and Wahyuri, A. S. (2018) Pembentukan Kondisi Fisik. Depok: PT Raja Grafindo Persada.
  6. Berawi, K. N. and Agverianti, T. (2017) ‘Efek Aktivitas Fisik pada Proses Pembentukan Radikal Bebas sebagai Faktor Risiko Aterosklerosis’, Jurnal Majority, 6(2), pp. 86–91.
  7. Bongga, S. (2018) ‘Respon Akut Olahraga Futsal Malam Terhadap Kadar Interleukin-6 Pada Individu Dewasa Muda’, Jurnal Dinamika, 9(2), pp. 29–34.
  8. Budiwanto, S. (2012) Metodologi Latihan Olahraga. Malang: Fakultas Ilmu Kedokteran Universitas Negeri Malang.
  9. Candrawati, Susiana (2013) ‘Pengaruh Aktivitas Fisik Terhadap Stres Oksidatif’, Mandala of Health, 6(1), pp. 454–61.
  10. Cornish, S. M. and Johnson, S. T. (2014) ‘Systemic cytokine response to three bouts of eccentric exercise’, Results in Immunology, 4(1), pp. 23–29. doi: 10.1016/j.rinim.2014.04.002.
  11. Fazio, E. et al. (2008) ‘Circulating β-endorphin, adrenocorticotrophic hormone and cortisol levels of stallions before and after short road transport: Stress effect of different distances’, Acta Veterinaria Scandinavica, 50(6), pp. 1–7. doi: 10.1186/1751-0147-50-6.
  12. Hamzah, M. S. et al. (2018) ‘Peran Transforming Growth Factor-`Β Pada Reaksi Eritema Nodosum Leprosum Berulang’, MDIV, 45(4), pp. 173–177.
  13. Harapan, H. et al. (2018) ‘Attitudes towards Zika virus infection among medical doctors in Aceh province, Indonesia’, Journal of Infection and Public Health, 11(1), pp. 99–104. doi: 10.1016/j.jiph.2017.06.013.
  14. Hayati (2014) ‘Dampak Latihan Intensitas Berat Pada Fungsi Imun Tubuh’, Embrio, 4, pp. 50–56. doi: 10.36456/embrio.vol4.no0.a1234.
  15. Hidayanti, M. D., Astuti, S. and Kustyawati, M. (2014) ‘Pengaruh Pemberian “Kombucha†Teh Rosella Terhadap Profil Darah Mencit (Mus musculus L)’, Jurnal Agritech, 34(04), p. 382.
  16. Kang, S. et al. (2019) ‘Targeting Interleukin-6 Signaling in Clinic’, Immunity, 50(4), pp. 1007–1023. doi: 10.1016/j.immuni.2019.03.026.
  17. Neil, A. kelly (2011) ‘The Effect of Total Work Performed During Acute Heavy Resistance Exercise on Circulating Lymphocytes in Untrained Men’, University of Connecticut, 1, pp. 1–45.
  18. Noorhasanah, E. (2017) ‘Differences influence of light and medium aerobic exercise activities to sitokin titors projectivity tumor necrosis factor (TNF-α) in teenagers’, Caring Noursing Journal, 1(1), pp. 21–28.
  19. Prabowo, Y. (2019) Profil Kesehatan Provinsi Jawa Tengah Tahun 2018, Dinas Kesehatan Provinsi Jawa Tengah.
  20. Purwanto (2011) ‘Dampak Senam Aerobik terhadap Daya Tahan Tubuh dan Penyakit’, Jurnal Media Ilmu Keolahragaan Indonesia, 1(1), pp. 1–9. doi: 10.15294/miki.v1i1.1128.
  21. Riyanto, A. (2011) Aplikasi Metodologi Penelitian Kesehatan. Yogyakarta: Nuha Medika.
  22. Sandy, F. F. et al. (2019) ‘Hubungan Aktivitas Fisik Terhadap Nilai Limfosit, Leukosit, Monosit dan Alergi lain Pada Mahasiswa Angkatan 2016 Shift A Fakultas Farmasi Universitas Padjadjaran’, Farmaka, 17(2), pp. 213–221.
  23. Saputra, K. L., Tasripan, T. and Arifin, A. (2019) ‘Rancang Bangun Kendali Kecepatan Treadmill Menggunakan ECG Yang Divisualisasikan Menggunakan Virtual Reality’, Jurnal Teknik ITS, 8(1), pp. A17–A22. doi: 10.12962/j23373539.v8i1.38353.
  24. Shodiq, M. C. (2016) Pengaruh Latihan Fisik Submaksimal Terhadap Peningkatan Jumlah Sel Limfosit Pada Tikus Putih (Rattus Norvegicus Strain Wistar), Program Studi Ilmu Keolahragaan, Fakultas Ilmu Keolahragaan Universitas Negeri Malang. doi: 10.17977/jss.v4i2.6436.g2728.
  25. Sudiono, Janti (2014) Sistem Kekebalan Tubuh. Jakarta: Buku Kedokteran EGC.
  26. Tanaka, T., Narazaki, M. and Kishimoto, T. (2014) ‘Il-6 in inflammation, Immunity, And disease’, Cold Spring Harbor Perspectives in Biology, pp. 1–17. doi: 10.1101/cshperspect.a016295.
  27. Vionni, Arifputra, J. and Arifputra, Y. (2016) ‘Reaksi Kusta’, Cermin Dunia Kedokteran-242, 43(7), pp. 501–504.
  28. Wardhana, M. (2016) ‘Pengantar Psikoneuroimunologi’, Vaikuntha International Publication, pp. 1–183.
  29. Wibowo, N. et al. (2016) Pedoman Nasional Pelayanan Kedokteran Diagnosis dan Tatalaksana Pre-Eklampsia. Jakarta: Perkumpulan Obstetri dan Ginekologi Indonesia (POGI).
  30. Yasirin, A. et al. (2014) ‘Journal of Sport Sciences and Fitness’, Journal of Sport Sciences and Fitness, 3(3), pp. 1–6.
  31. Yuniarti, E. (2014) ‘Pengaruh Latihan Submaksimal Terhadap Kadar Interleukin-6 Pada Siswa Pusat Pendidikan Latihan Pelajar Sumatera Barat’, Jurnal Sainstek, 6(2), pp. 189–192.

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Sains Medika: Jurnal Kedokteran dan Kesehatan
is published by Fakultas Kedokteran Universitas Islam Sultan Agung Semarang, Indonesia.
Jl. Raya Kaligawe Km.4, PO BOX 1054/SM Semarang 50112
Website: https://fkunissula.ac.id/
Email: sainsmedika@unissula.ac.idsainsmedika@unissula.ac.id

ISSN: 2339-093X (Online) | 2085-1545 (Print)
DOI : 10.30659/sainsmed

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