The Effect of Moderate-Intensity Physical Exercise on Interleukin-6 Level and Lymphocyte Count in Leprosy Reaction Patient

Adryan Roy*  -  Medical Faculty of Sultan Agung Islamic University (UNISSULA) Jl. Raya Kaligawe Km.4 Semarang, PO.BOX 1054, 50112 Jawa Tengah, Indonesia
Taufiqurrachman Nasihun  -  Biochemistry Departement, Medical Faculty of Sultan Agung Islamic University, Semarang, Indonesia, Indonesia
Titiek Sumarawati  -  Chemistry Departement, Medical Faculty of Sultan Agung Islamic University, Semarang, Indonesia, Indonesia

(*) Corresponding Author
DOI: 10.30659/sainsmed.v12i1.11931

Introduction: Leprosy reaction is an immunity declining reaction marked with inflammation which may cause permanent disability. Physical exercise may improve body’s immune system. Objective: To prove the effect of moderate-intensity physical exercise on the interleukin-6 level and lymphocyte count in leprosy reaction patient.
Methods: The quasi-experimental research with pretest and posttest and a control group design used 30 respondents consisting of 14 interventions and 16 controls. The intervention group was given moderate-intensity physical exercise 60%-79% in the form of static cycle at a frequency of 4 times weekly, 150 minutes per week. Corticosteroid was always administered to the two groups as a standard therapy. The interleukin-6 level was measured using ELISA method and lymphocyte count was measured using hematology analyzer.
Result: The Mann-Whitney analysis shows that the mean difference in IL-6 level between pretest and posttest with the intervention group (-7.1429±25.2369) is significantly lower than that of the control group (8.8125±11.2025), p<0.05. On the contrary, the Independent t-test analysis shows that the mean difference in lymphocyte count between pretest and posttest with the intervention group (0.7407±0.41236) is significantly higher than that of the control group (-0.4500±0.42415), p<0.05.
Conclusion: Physical exercise at moderate intensity in the form of aerobics using static cycle at a frequency of 4 times weekly, with duration of 150 minutes per week decreases interleukin-6 level and increases lymphocyte count in leprosy reaction patient.

 

Keywords: moderate-intensity exercise; IL-6; lymphocyte

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Sains Medika: Jurnal Kedokteran dan Kesehatan
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ISSN: 2339-093X (Online) | 2085-1545 (Print)
DOI : 10.30659/sainsmed

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