Results Characteristics of Lipid Profile Examination of Acute Ischemia Stroke Patients at RSUP Dr. Soedono Madiun, East Java

Dinik Wuryani*  -  Department of Neurology Dr. Soedono Madiun, East Java, Indonesia
Rissito Centricia Darumurti  -  Faculty of Medicine Universitas Islam Indonesia, Yogyakarta, Indonesia

(*) Corresponding Author

Introduction: Dyslipidemia as reflected in the results of lipid profile examination is among the most common abnormalities found in acute ischemic stroke patients. Studies assessing the characteristic of these results may provide a foundation for an effective plan of treatment and prevention to overcome the burden of the disease.

Objective: To study the characteristic of the results of lipid profile examination among acute ischemic stroke patients at Dr. Soedono General Hospital, Madiun, East Java.

Methods: This research is a descriptive study with a cross-sectional approach using secondary data taken from the medical records of acute ischemic stroke inpatients at the Stroke Unit of Dr. Soedono General Hospital, Madiun, East Java admitted in January-December 2015. Results of lipid profile examination consisting of total cholesterol, LDL, HDL, and triglycerides were categorized as high, normal, and low based on their respective levels.

Results: There were 72 subjects selected using simple random sampling. Level of total cholesterol was high in 52.78%, normal in 36.11%, and low in 11.11% of the subjects. Level of LDL was high in 54.17%, normal in 22.22%, and low in 23.61% of the subjects. Level of HDL was low in 31.94%, normal in 50.00%, and high in 18.06% of the subjects. Level of triglycerides was high in 26.39%, normal in 33.33%, and low in 40.28% of the subjects.

Conclusion: Total cholesterol and LDL are generally high, HDL is generally normal, while triglycerides is generally low among acute ischemic stroke patients in Dr. Soedono General Hospital, Madiun, East Java.

Keywords: Lipid Profile; Dyslipidemia; Acute Ischemic Stroke

  1. Antonios, N., Angiolillo, D.J., dan Silliman, S., 2008, Hypertriglyceridemia and ischemic stroke, European Neurology, 60(6):269-278., diakses pada 23 Desember 2016.
  2. Antonios, N. dan Silliman, S., 2009, Management of cholesterol in patients with ischemic stroke, dalam: J.D. Geyer dan C.R. Gomez (eds), Stroke: A Practical Approach, Philadelphia: Lippincott Williams & Wilkins.
  3. Badan Penelitian dan Pengembangan Kesehatan Departemen Kesehatan Republik Indonesia, 2008, Riset Kesehatan Dasar 2007, Jakarta: Departemen Kesehatan Republik Indonesia.
  4. Badan Penelitian dan Pengembangan Kesehatan Kementrian Kesehatan Republik Indonesia, 2013, Riset Kesehatan Dasar 2013, Jakarta: Kementrian Kesehatan Republik Indonesia.
  5. Bentzon, J., Otsuka, F., Virmani, R., dan Falk, E., 2014, Mechanisms of plaque formation and rupture, Circulation Research, 114(12):1852-1866.
  6. circresaha.114.302721, diakses pada 23 Desember 2016.
  7. Bharosay, A., Bharosay, V., Bandyopadhyay, D., Sodani, A., Varma, M., et al, 2013, Effect of Lipid Profile Upon Prognosis in Ischemic and Haemorrhagic Cerebrovascular Stroke, Indian Journal of Clinical Biochemistry, 29(3):372-376.
  8. pmc/articles/PMC4062664 , diakses pada 25 September 2016.
  9. Biswas, N. dan Sangma, M.A., 2017, Serum LDL (low density lipoprotein) as a risk factor for ischemic stroke, Mymensingh Medical Journal, 25(3):425-32. http://
  10., diakses pada 23 Desember 2016.
  11. Bradac, G., 2014, Cerebral Angiography: Normal Anatomy and Vascular Pathology, 2nd ed, Berlin: Springer.
  12. Caso, V., Paciaroni, M., Agnelli, G., Corea, F., Ageno, W., et al., 2010, Gender differences in patients with acute ischemic stroke, Women's Health, 6(1):51-57.
  13. 2217/whe.09.82, diakses pada 23 Desember 2016.
  14. Di Carlo, A., 2008, Human and economic burden of stroke, Age and Ageing, 38(1):4-5., diakses pada 25 September 2016.
  15. Fahimfar, N., Khalili, D., Mohebi, R., Azizi, F., dan Hadaegh, F., 2012, Risk factors for ischemic stroke; results from 9 years of follow-up in a population based cohort of Iran, BioMed Central Neurology, 12(1)., diakses pada 23 Desember 2016.
  16. Feigin, V., Krishnamurthi, R., Parmar, P., Norrving, B., Mensah, G., et al, 2015, Update on the Global Burden of Ischemic and Hemorrhagic Stroke in 1990-2013: The GBD 2013 Study, Neuroepidemiology, 45(3):161-176.
  17. , diakses pada 25 September 2016.
  18. Finkelstein, E., Chay, J., dan Bajpai, S., 2014., The economic burden of self-reported and undiagnosed cardiovascular diseases and diabetes on Indonesian households, Public Library of Science, 9(6):e99572.
  19. 1371/journal.pone.0099572, diakses pada 25 September 2016.
  20. Freiberg, J.J., Tybjaerg-Hansen, A., Jensen, J.S., dan Nordestgaard, B.G., 2008, Nonfasting triglycerides and risk of ischemic stroke in the general population, Journal of the American Medical Association, 300(18): 2142.
  21. jama.2008.621, diakses pada 23 Desember 2016.
  22. Gezmu, T., Schneider, D., Demissie, K., Giordano, C., Gizzi, M., et al., 2014, Lipid profiles and ischemic stroke risk: variations by sex within racial/ethnic groups, International Journal Of Women's Health, 6:585-595., diakses pada 23 Desember 2016.
  23. Hao, W. dan Friedman, A., 2014, The LDL-HDL profile determines the risk of atherosclerosis: a mathematical model, Public Library of Science, 9(3):e90497., diakses pada 23 Desember 2016.
  24. Iso, H., Jacobs, D., Wentworth, D., Neaton, J., dan Cohen, J., 1989, Serum cholesterol levels and six-year mortality from stroke in 350,977 men screened for the Multiple Risk Factor Intervention Trial, New England Journal Of Medicine, 320(14):904-910., diakses pada 23 Desember 2016.
  25. Karim, M., Mondal, S.K., Kabir, A.H., Das, P.P., Biswas, S., et al., 2016, Association of hypertriglyceridemia with ischemic stroke: study in a tertiary care hospital in Bangladesh, Journal of Medicine, 17:21-26.
  26. jom.v17i1.30054, diakses pada 23 Desember 2016.
  27. Koba, S. dan Hirano, T., 2011, Dyslipidemia and atherosclerosis, Nihon Rinsho, 69(1):138-143., diakses pada 25 September 2016.
  28. Leonards, C., Ebinger, M., Batluk, J., Malzahn, U., Heuschmann, P., dan Endress, M., 2010, The role of fasting versus non-fasting triglycerides in ischemic stroke: a systematic review, Frontiers In Neurology, 1., diakses pada 23 Desember 2016.
  29. Libby, P., 2009, Lipoproteins: mechanisms for atherogenesis and progression of atherothrombotic disease, dalam: C.M. Ballantyne (ed), Clinical Lipidology: A Companion to Braunwald’s Heart Disease, 1st ed, Philadelphia: Saunders.
  30. Mackay, J., Mensah, G., Mendis, S., dan Greenlund, K., 2004, The Atlas of Heart Disease and Stroke, 1st ed, Geneva: World Health Organization.
  31. McGrowder, D., Riley, C., Morrison, E., dan Gordon, L., 2011, The role of high-density lipoproteins in reducing the risk of vascular diseases, neurogenerative disorders, and cancer, Cholesterol, 2011:1-9., diakses pada 23 Desember 2016.
  32. Mendis, S., Puska, P., dan Norrving, B., 2011, Global Atlas on Cardiovascular Disease Prevention and Control, Geneva: World Health Organization in collaboration with the World Heart Federation and the World Stroke Organization.
  33. Mirghani, Z. dan Zein, T., 2009, Total and LDL cholesterol as risk factors of ischemic stroke in Emirati patients, The Internet Journal Of Neurology, 13(1).
  34. 5580/fa8, diakses pada 23 Desember 2016.
  35. Saeed, E., Ali, R., Jalaluddin, M., Saeed, A., Jadoon, R., et al., 2015, Hypercholesterolemia in patients of ischemic stroke, Journal Of Ayub Medical College Abbottabad, 27(3):637-639., diakses pada 23 Desember 2016.
  36. Sharmin, N., Sultana, N., Mazumder, P., dan Rahman, T., 2015, Serum calcium and lipid profile in acute ischemic stroke, Bangladesh Journal of Medical Science,
  37. (3):286–289.
  38. , diakses pada 25 September 2016.
  39. Strong, K., Mathers, C., dan Bonita, R., 2007, Preventing stroke: saving lives around the world, The Lancet Neurology, 6(2):182-187.
  40. , diakses pada 25 September 2016.
  41. Yao, X., Lin, Y., Geng, J., Sun, Y., Chen, Y., et al. 2012. Age- and gender-specific prevalence of risk factors in patients with first-ever ischemic stroke in China. Stroke Research And Treatment, 2012., diakses pada
  42. Desember 2016.
  43. Young, J. and Forster, A., 2007, Review of stroke rehabilitation, British Medical Journal, 334(7584):86-90.
  44. e1abab6355f8fec86cfec3394d6aac2&keytype2=tf_ipsecsha, diakses pada 25 September 2016.

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ISSN: 2339-093X (Online) | 2085-1545 (Print)
DOI : 10.30659/sainsmed

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